An overall picture of chemokine receptors: Basic research and drug development

Li Chen, Gang Pei, Wenbo Zhang

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Chemokine receptors belong to the transmembrane G protein coupled receptor (GPCR) family. Although a major physiological role of chemokine receptors is for host defense by recruitment of lymphocytes to inflammatory sites, they are now found to be involved in more processes such as virus infection, tumor genesis and metastasis, and embryologic development. In this review, we show an overall picture of chemokine receptors in structure, signal transduction and modulation, physiological and pathological roles, and applying chemokine receptors for drug discovery.

Original languageEnglish (US)
Pages (from-to)1045-1055
Number of pages11
JournalCurrent Pharmaceutical Design
Volume10
Issue number9
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

Keywords

  • Agonist
  • Antagonist
  • Chemokine receptor
  • Chemotaxis
  • Drug discovery
  • G protein coupled receptor
  • Ligand
  • Signal transduction

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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