Abstract
Chemokine receptors belong to the transmembrane G protein coupled receptor (GPCR) family. Although a major physiological role of chemokine receptors is for host defense by recruitment of lymphocytes to inflammatory sites, they are now found to be involved in more processes such as virus infection, tumor genesis and metastasis, and embryologic development. In this review, we show an overall picture of chemokine receptors in structure, signal transduction and modulation, physiological and pathological roles, and applying chemokine receptors for drug discovery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1045-1055 |
| Number of pages | 11 |
| Journal | Current Pharmaceutical Design |
| Volume | 10 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2004 |
| Externally published | Yes |
Keywords
- Agonist
- Antagonist
- Chemokine receptor
- Chemotaxis
- Drug discovery
- G protein coupled receptor
- Ligand
- Signal transduction
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery