An overview of animal models for arthropod-borne viruses

Erin S. Reynolds, Charles E. Hart, Meghan E. Hermance, Douglas L. Brining, Saravanan Thangamani

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Arthropod-borne viruses (arboviruses) have continued to emerge in recent years, posing a significant health threat to millions of people worldwide. The majority of arboviruses that are pathogenic to humans are transmitted by mosquitoes and ticks, but other types of arthropod vectors can also be involved in the transmission of these viruses. To alleviate the health burdens associated with arbovirus infections, it is necessary to focus today's research on disease control and therapeutic strategies. Animal models for arboviruses are valuable experimental tools that can shed light on the pathophysiology of infection and will enable the evaluation of future treatments and vaccine candidates. Ideally an animal model will closely mimic the disease manifestations observed in humans. In this review, we outline the currently available animal models for several viruses vectored by mosquitoes, ticks, and midges, for which there are no standardly available vaccines or therapeutics.

Original languageEnglish (US)
Pages (from-to)232-241
Number of pages10
JournalComparative Medicine
Issue number3
StatePublished - Jun 2017

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Veterinary


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