An overview of chagasic cardiomyopathy: Pathogenic importance of oxidative stress

Michele A. Zacks, Jian Jun Wen, Galina Vyatkina, Vandanajay Bhatia, Nisha Garg

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

There is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stress-induced injuries that may contribute to disease progression. Pathogen invasion- and replication-mediated cellular injuries and immune-mediated cytotoxic reactions are the common source of reactive oxygen species (ROS) in infectious etiologies. However, our understanding of the source and role of oxidative stress in chagasic cardiomyopathy (CCM) remains incomplete. In this review, we discuss the evidence for increased oxidative stress in chagasic disease, with emphasis on mitochondrial abnormalities, electron transport chain dysfunction and its role in sustaining oxidative stress in myocardium. We discuss the literature reporting the consequences of sustained oxidative stress in CCM pathogenesis.

Original languageEnglish (US)
Pages (from-to)695-715
Number of pages21
JournalAnais da Academia Brasileira de Ciencias
Volume77
Issue number4
StatePublished - Dec 2005

    Fingerprint

Keywords

  • Chagasic cardiomyopathy
  • Inflammation
  • Mitochondria
  • Oxidant/antioxidant status
  • Oxidative damage
  • Reactive oxygen species

ASJC Scopus subject areas

  • General

Cite this