An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy

Srinivasa Reddy Bonam; Charalambos D. Partidos; Sampath Kumar M. Halmuthur; Sylviane Muller

doi:10.1016/j.tips.2017.06.002

An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy

Srinivasa Reddy Bonam, Charalambos D. Partidos, Sampath Kumar M. Halmuthur, Sylviane Muller

Research output: Contribution to journal › Review article › peer-review

200 Scopus citations

Abstract

Adjuvants incorporated in prophylactic and/or therapeutic vaccine formulations impact vaccine efficacy by enhancing, modulating, and/or prolonging the immune response. In addition, they reduce antigen concentration and the number of immunizations required for protective efficacy, therefore contributing to making vaccines more cost effective. Our better understanding of the molecular mechanisms of immune recognition and protection has led research efforts to develop new adjuvants that are currently at various stages of development or clinical evaluation.

Original language	English (US)
Pages (from-to)	771-793
Number of pages	23
Journal	Trends in Pharmacological Sciences
Volume	38
Issue number	9
DOIs	https://doi.org/10.1016/j.tips.2017.06.002
State	Published - Sep 2017
Externally published	Yes

Keywords

CpG ODNs
QS-21
delivery systems
lipopeptides
new adjuvants
patents
vaccines

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1016/j.tips.2017.06.002

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title = "An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy",

abstract = "Adjuvants incorporated in prophylactic and/or therapeutic vaccine formulations impact vaccine efficacy by enhancing, modulating, and/or prolonging the immune response. In addition, they reduce antigen concentration and the number of immunizations required for protective efficacy, therefore contributing to making vaccines more cost effective. Our better understanding of the molecular mechanisms of immune recognition and protection has led research efforts to develop new adjuvants that are currently at various stages of development or clinical evaluation.",

keywords = "CpG ODNs, QS-21, delivery systems, lipopeptides, new adjuvants, patents, vaccines",

author = "Bonam, {Srinivasa Reddy} and Partidos, {Charalambos D.} and Halmuthur, {Sampath Kumar M.} and Sylviane Muller",

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AU - Muller, Sylviane

PY - 2017/9

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AB - Adjuvants incorporated in prophylactic and/or therapeutic vaccine formulations impact vaccine efficacy by enhancing, modulating, and/or prolonging the immune response. In addition, they reduce antigen concentration and the number of immunizations required for protective efficacy, therefore contributing to making vaccines more cost effective. Our better understanding of the molecular mechanisms of immune recognition and protection has led research efforts to develop new adjuvants that are currently at various stages of development or clinical evaluation.

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KW - QS-21

KW - delivery systems

KW - lipopeptides

KW - new adjuvants

KW - patents

KW - vaccines

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An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy

Abstract

Keywords

ASJC Scopus subject areas

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