An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy

Srinivasa Reddy Bonam, Charalambos D. Partidos, Sampath Kumar M. Halmuthur, Sylviane Muller

Research output: Contribution to journalReview articlepeer-review

186 Scopus citations

Abstract

Adjuvants incorporated in prophylactic and/or therapeutic vaccine formulations impact vaccine efficacy by enhancing, modulating, and/or prolonging the immune response. In addition, they reduce antigen concentration and the number of immunizations required for protective efficacy, therefore contributing to making vaccines more cost effective. Our better understanding of the molecular mechanisms of immune recognition and protection has led research efforts to develop new adjuvants that are currently at various stages of development or clinical evaluation.

Original languageEnglish (US)
Pages (from-to)771-793
Number of pages23
JournalTrends in Pharmacological Sciences
Volume38
Issue number9
DOIs
StatePublished - Sep 2017
Externally publishedYes

Keywords

  • CpG ODNs
  • QS-21
  • delivery systems
  • lipopeptides
  • new adjuvants
  • patents
  • vaccines

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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