An update on the pathology and clinical management of gouty arthritis

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Gouty arthritis is an inflammatory condition associated with debilitating clinical symptoms, functional impairments, and a substantial impact on quality of life. This condition is initially triggered by the deposition of monosodium urate crystals into the joint space. This causes an inflammatory cascade resulting in the secretion of several proinflammatory cytokines and neutrophil recruitment into the joint. While generally effective, currently available agents are associated with a number of adverse events and contraindications that complicate their use. Based on our increased understanding of the inflammatory pathogenesis of gouty arthritis, several new agents are under development that may provide increased efficacy and reduced toxicity.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalClinical Rheumatology
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • Chronic diseases
  • Gouty arthritis
  • Inflammation
  • Pathophysiology

ASJC Scopus subject areas

  • Rheumatology

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