An update on the use of massive transfusion protocols in obstetrics

Luis Pacheco, George Saade, Maged Costantine, Steven L. Clark, Gary Hankins

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    Obstetrical hemorrhage remains a leading cause of maternal mortality worldwide. New concepts involving the pathophysiology of hemorrhage have been described and include early activation of both the protein C and fibrinolytic pathways. New strategies in hemorrhage treatment include the use of hemostatic resuscitation, although the optimal ratio to administer the various blood products is still unknown. Massive transfusion protocols involve the early utilization of blood products and limit the traditional approach of early massive crystalloid-based resuscitation. The evidence behind hemostatic resuscitation has changed in the last few years, and debate is ongoing regarding optimal transfusion strategies. The use of tranexamic acid, fibrinogen concentrates, and prothrombin complex concentrates has emerged as new potential alternative treatment strategies with improved safety profiles.

    Original languageEnglish (US)
    Pages (from-to)340-344
    Number of pages5
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume214
    Issue number3
    DOIs
    StatePublished - Mar 1 2016

    Fingerprint

    Resuscitation
    Obstetrics
    Hemostatics
    Hemorrhage
    Tranexamic Acid
    Maternal Mortality
    Protein C
    Fibrinogen
    Safety
    Therapeutics
    prothrombin complex concentrates
    crystalloid solutions

    Keywords

    • hemostatic resuscitation
    • massive transfusion
    • obstetrical hemorrhage

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

    Cite this

    An update on the use of massive transfusion protocols in obstetrics. / Pacheco, Luis; Saade, George; Costantine, Maged; Clark, Steven L.; Hankins, Gary.

    In: American Journal of Obstetrics and Gynecology, Vol. 214, No. 3, 01.03.2016, p. 340-344.

    Research output: Contribution to journalArticle

    Pacheco, Luis ; Saade, George ; Costantine, Maged ; Clark, Steven L. ; Hankins, Gary. / An update on the use of massive transfusion protocols in obstetrics. In: American Journal of Obstetrics and Gynecology. 2016 ; Vol. 214, No. 3. pp. 340-344.
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