An Update on Vaccines Against Trypanosoma cruzi and Chagas Disease

Nisha J. Garg

doi:10.3390/pathogens14020124

An Update on Vaccines Against Trypanosoma cruzi and Chagas Disease

Nisha J. Garg

Microbiology And Immunology

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Chagas disease (CD) is a global health concern, with no existing therapies to prophylactically treat adults traveling to endemic countries or those who may already be infected with Trypanosoma cruzi. The economic burden of Chagas cardiomyopathy and heart failure, due to healthcare costs and lost productivity from premature deaths, provides a strong rationale for investment in the development of immune therapies against CD. Vaccine efficacy is proposed to depend heavily on the induction of a robust Th1 response for the clearance of intracellular pathogens like T. cruzi. In this review, updated information on the efforts for vaccine development against CD is provided.

Original language	English (US)
Article number	124
Journal	Pathogens
Volume	14
Issue number	2
DOIs	https://doi.org/10.3390/pathogens14020124
State	Published - Feb 2025

Keywords

Chagas
Trypanosoma cruzi
vaccine

ASJC Scopus subject areas

Immunology and Allergy
Molecular Biology
General Immunology and Microbiology
Microbiology (medical)
Infectious Diseases

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10.3390/pathogens14020124

Cite this

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title = "An Update on Vaccines Against Trypanosoma cruzi and Chagas Disease",

abstract = "Chagas disease (CD) is a global health concern, with no existing therapies to prophylactically treat adults traveling to endemic countries or those who may already be infected with Trypanosoma cruzi. The economic burden of Chagas cardiomyopathy and heart failure, due to healthcare costs and lost productivity from premature deaths, provides a strong rationale for investment in the development of immune therapies against CD. Vaccine efficacy is proposed to depend heavily on the induction of a robust Th1 response for the clearance of intracellular pathogens like T. cruzi. In this review, updated information on the efforts for vaccine development against CD is provided.",

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AB - Chagas disease (CD) is a global health concern, with no existing therapies to prophylactically treat adults traveling to endemic countries or those who may already be infected with Trypanosoma cruzi. The economic burden of Chagas cardiomyopathy and heart failure, due to healthcare costs and lost productivity from premature deaths, provides a strong rationale for investment in the development of immune therapies against CD. Vaccine efficacy is proposed to depend heavily on the induction of a robust Th1 response for the clearance of intracellular pathogens like T. cruzi. In this review, updated information on the efforts for vaccine development against CD is provided.

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An Update on Vaccines Against Trypanosoma cruzi and Chagas Disease

Abstract

Keywords

ASJC Scopus subject areas

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