Anabolic effects of oxandrolone after severe burn

D. W. Hart, Steven Wolf, P. I. Ramzy, D. L. Chinkes, R. B. Beauford, A. A. Ferrando, R. R. Wolfe, David Herndon

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

Objective: To explore the hypothesis that oxandrolone may reverse muscle catabolism in cachectic, critically ill pediatric burn patients. Summary Background Data: Severe burn causes exaggerated muscle protein catabolism, contributing to weakness and delayed healing. Oxandrolone is an anabolic steroid that has been used in cachectic hepatitis and AIDS patients. Methods: Fourteen severely burned children were enrolled during a 5-month period in a prospective cohort analytic study. There was a prolonged delay in the arrival of these patients to the burn unit for definitive care. This neglect of skin grafting and nutritional support resulted in critically ill children with significant malnutrition. On arrival, all patients underwent excision and skin grafting and received similar clinical care. Subjects were studied 5 to 7 days after admission, and again after 1 week of oxandrolone treatment at 0.1 mg/kg by mouth twice daily or no pharmacologic treatment. Muscle protein kinetics were derived from femoral arterial and venous blood samples and vastus lateralis muscle biopsies during a stable isotope infusion. Results: Control and oxandrolone subjects were similar in age, weight, and percentage of body surface area burned. Muscle protein net balance decreased in controls and improved in the oxandrolone group. The improvement in the oxandrolone group was associated with increased protein synthesis efficiency. Muscle protein breakdown was unchanged. Conclusions: In burn victims, oxandrolone improves muscle protein metabolism through enhanced protein synthesis efficiency. These findings suggest the efficacy of oxandrolone in impeding muscle protein catabolism in cachectic, critically injured children.

Original languageEnglish (US)
Pages (from-to)556-564
Number of pages9
JournalAnnals of Surgery
Volume233
Issue number4
DOIs
StatePublished - 2001

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Oxandrolone
Anabolic Agents
Muscle Proteins
Skin Transplantation
Critical Illness
Testosterone Congeners
Burn Units
Muscles
Nutritional Support
Body Surface Area
Quadriceps Muscle
Thigh
Malnutrition
Isotopes
Hepatitis
Mouth
Acquired Immunodeficiency Syndrome
Proteins
Cohort Studies
Pediatrics

ASJC Scopus subject areas

  • Surgery

Cite this

Hart, D. W., Wolf, S., Ramzy, P. I., Chinkes, D. L., Beauford, R. B., Ferrando, A. A., ... Herndon, D. (2001). Anabolic effects of oxandrolone after severe burn. Annals of Surgery, 233(4), 556-564. https://doi.org/10.1097/00000658-200104000-00012

Anabolic effects of oxandrolone after severe burn. / Hart, D. W.; Wolf, Steven; Ramzy, P. I.; Chinkes, D. L.; Beauford, R. B.; Ferrando, A. A.; Wolfe, R. R.; Herndon, David.

In: Annals of Surgery, Vol. 233, No. 4, 2001, p. 556-564.

Research output: Contribution to journalArticle

Hart, DW, Wolf, S, Ramzy, PI, Chinkes, DL, Beauford, RB, Ferrando, AA, Wolfe, RR & Herndon, D 2001, 'Anabolic effects of oxandrolone after severe burn', Annals of Surgery, vol. 233, no. 4, pp. 556-564. https://doi.org/10.1097/00000658-200104000-00012
Hart DW, Wolf S, Ramzy PI, Chinkes DL, Beauford RB, Ferrando AA et al. Anabolic effects of oxandrolone after severe burn. Annals of Surgery. 2001;233(4):556-564. https://doi.org/10.1097/00000658-200104000-00012
Hart, D. W. ; Wolf, Steven ; Ramzy, P. I. ; Chinkes, D. L. ; Beauford, R. B. ; Ferrando, A. A. ; Wolfe, R. R. ; Herndon, David. / Anabolic effects of oxandrolone after severe burn. In: Annals of Surgery. 2001 ; Vol. 233, No. 4. pp. 556-564.
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