Analysis and predictive modeling of asthma phenotypes

Allan R. Brasier, Hyunsu Ju

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Molecular classification using robust biochemical measurements provides a level of diagnostic precision that is unattainable using indirect phenotypic measurements. Multidimensional measurements of proteins, genes, or metabolites (analytes) can identify subtle differences in the pathophysiology of patients with asthma in a way that is not otherwise possible using physiological or clinical assessments. We overview a method for relating biochemical analyte measurements to generate predictive models of discrete (categorical) clinical outcomes, a process referred to as "supervised classification." We consider problems inherent in wide (small n and large p ) high-dimensional data, including the curse of dimensionality, collinearity and lack of information content. We suggest methods for reducing the data to the most informative features. We describe different approaches for phenotypic modeling, using logistic regression, classification and regression trees, random forest and nonparametric regression spline modeling. We provide guidance on post hoc model evaluation and methods to evaluate model performance using ROC curves and generalized additive models. The application of validated predictive models for outcome prediction will significantly impact the clinical management of asthma.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages273-288
Number of pages16
Volume795
ISBN (Print)9781461486022
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume795
ISSN (Print)00652598

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Keywords

  • False discovery rate
  • Feature reduction
  • Generalized additive models (GAMs)
  • Logistic regression
  • Multivariate adaptive regression splines (MARS)
  • Multivariate analysis
  • Random forest
  • Receiver operating characteristic (ROC) curve
  • Significance of microarrays (SAM)
  • Supervised learning

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Brasier, A. R., & Ju, H. (2014). Analysis and predictive modeling of asthma phenotypes. In Advances in Experimental Medicine and Biology (Vol. 795, pp. 273-288). (Advances in Experimental Medicine and Biology; Vol. 795). Springer New York LLC. https://doi.org/10.1007/978-1-4614-8603-9_17