Analysis of 2-[Fluorine-18]-Fluoro-2-deoxy-D-glucose Uptake Kinetics in PET Studies of Pulmonary Inflammation

Tobias Schroeder; Marcos F. Vidal Melo; Jose G. Venegas

doi:10.1016/j.acra.2010.11.019

Analysis of 2-[Fluorine-18]-Fluoro-2-deoxy-D-glucose Uptake Kinetics in PET Studies of Pulmonary Inflammation

Tobias Schroeder, Marcos F. Vidal Melo, Jose G. Venegas

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Dynamic positron emission tomography (PET) imaging of the lung using the radiotracer 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (¹⁸F-FDG) is an emerging method to assess noninvasively the metabolic activity of pulmonary inflammatory cells. Nevertheless, because of the distinct functional and structural characteristics of inflamed lung tissue standard methods of ¹⁸F-FDG analysis can be substantially limited and there is no consensus about the best method for quantification of the ¹⁸F-FDG signal for acute or chronic inflammatory lung diseases. This article gives an overview on recent advances in quantitative analysis of ¹⁸F-FDG uptake kinetics in non-neoplastic inflamed lung tissue.

Original language	English (US)
Pages (from-to)	418-423
Number of pages	6
Journal	Academic Radiology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.acra.2010.11.019
State	Published - Apr 2011
Externally published	Yes

Keywords

Acute respiratory distress syndrome
Chronic obstructive pulmonary disease
Compartmental modeling
Cystic fibrosis
FDG
Lung inflammation
Positron emission tomography
Radionuclide imaging

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.acra.2010.11.019

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title = "Analysis of 2-[Fluorine-18]-Fluoro-2-deoxy-D-glucose Uptake Kinetics in PET Studies of Pulmonary Inflammation",

abstract = "Dynamic positron emission tomography (PET) imaging of the lung using the radiotracer 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18F-FDG) is an emerging method to assess noninvasively the metabolic activity of pulmonary inflammatory cells. Nevertheless, because of the distinct functional and structural characteristics of inflamed lung tissue standard methods of 18F-FDG analysis can be substantially limited and there is no consensus about the best method for quantification of the 18F-FDG signal for acute or chronic inflammatory lung diseases. This article gives an overview on recent advances in quantitative analysis of 18F-FDG uptake kinetics in non-neoplastic inflamed lung tissue.",

keywords = "Acute respiratory distress syndrome, Chronic obstructive pulmonary disease, Compartmental modeling, Cystic fibrosis, FDG, Lung inflammation, Positron emission tomography, Radionuclide imaging",

author = "Tobias Schroeder and {Vidal Melo}, {Marcos F.} and Venegas, {Jose G.}",

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AU - Vidal Melo, Marcos F.

AU - Venegas, Jose G.

PY - 2011/4

Y1 - 2011/4

N2 - Dynamic positron emission tomography (PET) imaging of the lung using the radiotracer 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18F-FDG) is an emerging method to assess noninvasively the metabolic activity of pulmonary inflammatory cells. Nevertheless, because of the distinct functional and structural characteristics of inflamed lung tissue standard methods of 18F-FDG analysis can be substantially limited and there is no consensus about the best method for quantification of the 18F-FDG signal for acute or chronic inflammatory lung diseases. This article gives an overview on recent advances in quantitative analysis of 18F-FDG uptake kinetics in non-neoplastic inflamed lung tissue.

AB - Dynamic positron emission tomography (PET) imaging of the lung using the radiotracer 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18F-FDG) is an emerging method to assess noninvasively the metabolic activity of pulmonary inflammatory cells. Nevertheless, because of the distinct functional and structural characteristics of inflamed lung tissue standard methods of 18F-FDG analysis can be substantially limited and there is no consensus about the best method for quantification of the 18F-FDG signal for acute or chronic inflammatory lung diseases. This article gives an overview on recent advances in quantitative analysis of 18F-FDG uptake kinetics in non-neoplastic inflamed lung tissue.

KW - Acute respiratory distress syndrome

KW - Chronic obstructive pulmonary disease

KW - Compartmental modeling

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KW - Positron emission tomography

KW - Radionuclide imaging

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Analysis of 2-[Fluorine-18]-Fluoro-2-deoxy-D-glucose Uptake Kinetics in PET Studies of Pulmonary Inflammation

Abstract

Keywords

ASJC Scopus subject areas

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