Analysis of association between maternal tumor necrosis factor-α promoter polymorphism (-308), tumor necrosis factor concentration, and preterm birth

Ramkumar Menon, Mario Merialdi, Ana P. Betrán, Siobhan Dolan, Lan Jiang, Stephen J. Fortunato, Scott Williams

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Objective: This study was undertaken to investigate the association of tumor necrosis factor-α (TNF-α) single nucleotide polymorphism (G-308>A) and risk of preterm birth by performing a systematic review and a meta-analysis of available studies. In addition, association between this variant and TNF-α concentration in amniotic fluid (AF) in preterm birth was also investigated. Study design: Articles were chosen based on a Medline and EMBASE searches (1990-2005) with no language restrictions. An ongoing case-control study conducted in Nashville, TN, was also included. Articles evaluating the association between G-308>A and preterm birth were screened according to specific inclusion criteria. Meta-analysis was performed by using a random effect model. Association between maternal -308 genotype and AF-TNF-α concentration was determined by sandwich immunoassays. Results: Titles and abstracts of 6851 citations identified through the search were screened. Including our own study, a total of 7 studies were included for meta-analysis. Only 2 reported a statistically significant increased risk based on -308 genotype. Meta-analysis of the case-control studies on a pooled dataset (a total of 1846 subjects, 638 cases, and 1208 controls) showed no significant association between the -308 genotype and the risk of preterm birth (odds ratio [OR] 1.41; CI 0.90-2.19). A nonsignificant increase of AF TNF-α concentration was demonstrated with the GG genotype in cases compared with the presence of allele A. Conclusion: Meta-analysis of available evidence documented no statistically significant association between a single nucleotide polymorphism in the TNF-α gene (G-308>A) and preterm birth. Analyses of AF-TNF-α concentration demonstrated no increase in TNF-α in the presence of the minor allele (A).These results suggest that this single nucleotide polymorphism does not independently associate strongly with preterm birth.

Original languageEnglish (US)
Pages (from-to)1240-1248
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Volume195
Issue number5
DOIs
StatePublished - Nov 2006
Externally publishedYes

Fingerprint

Premature Birth
Tumor Necrosis Factor-alpha
Mothers
Meta-Analysis
Amniotic Fluid
Genotype
Single Nucleotide Polymorphism
Case-Control Studies
Alleles
Immunoassay
Language
Odds Ratio
Genes

Keywords

  • Amniotic fluid
  • Cytokines
  • Meta-analysis
  • Prematurity
  • Single nucleotide polymorphisms
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Analysis of association between maternal tumor necrosis factor-α promoter polymorphism (-308), tumor necrosis factor concentration, and preterm birth. / Menon, Ramkumar; Merialdi, Mario; Betrán, Ana P.; Dolan, Siobhan; Jiang, Lan; Fortunato, Stephen J.; Williams, Scott.

In: American Journal of Obstetrics and Gynecology, Vol. 195, No. 5, 11.2006, p. 1240-1248.

Research output: Contribution to journalArticle

Menon, Ramkumar ; Merialdi, Mario ; Betrán, Ana P. ; Dolan, Siobhan ; Jiang, Lan ; Fortunato, Stephen J. ; Williams, Scott. / Analysis of association between maternal tumor necrosis factor-α promoter polymorphism (-308), tumor necrosis factor concentration, and preterm birth. In: American Journal of Obstetrics and Gynecology. 2006 ; Vol. 195, No. 5. pp. 1240-1248.
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AU - Menon, Ramkumar

AU - Merialdi, Mario

AU - Betrán, Ana P.

AU - Dolan, Siobhan

AU - Jiang, Lan

AU - Fortunato, Stephen J.

AU - Williams, Scott

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N2 - Objective: This study was undertaken to investigate the association of tumor necrosis factor-α (TNF-α) single nucleotide polymorphism (G-308>A) and risk of preterm birth by performing a systematic review and a meta-analysis of available studies. In addition, association between this variant and TNF-α concentration in amniotic fluid (AF) in preterm birth was also investigated. Study design: Articles were chosen based on a Medline and EMBASE searches (1990-2005) with no language restrictions. An ongoing case-control study conducted in Nashville, TN, was also included. Articles evaluating the association between G-308>A and preterm birth were screened according to specific inclusion criteria. Meta-analysis was performed by using a random effect model. Association between maternal -308 genotype and AF-TNF-α concentration was determined by sandwich immunoassays. Results: Titles and abstracts of 6851 citations identified through the search were screened. Including our own study, a total of 7 studies were included for meta-analysis. Only 2 reported a statistically significant increased risk based on -308 genotype. Meta-analysis of the case-control studies on a pooled dataset (a total of 1846 subjects, 638 cases, and 1208 controls) showed no significant association between the -308 genotype and the risk of preterm birth (odds ratio [OR] 1.41; CI 0.90-2.19). A nonsignificant increase of AF TNF-α concentration was demonstrated with the GG genotype in cases compared with the presence of allele A. Conclusion: Meta-analysis of available evidence documented no statistically significant association between a single nucleotide polymorphism in the TNF-α gene (G-308>A) and preterm birth. Analyses of AF-TNF-α concentration demonstrated no increase in TNF-α in the presence of the minor allele (A).These results suggest that this single nucleotide polymorphism does not independently associate strongly with preterm birth.

AB - Objective: This study was undertaken to investigate the association of tumor necrosis factor-α (TNF-α) single nucleotide polymorphism (G-308>A) and risk of preterm birth by performing a systematic review and a meta-analysis of available studies. In addition, association between this variant and TNF-α concentration in amniotic fluid (AF) in preterm birth was also investigated. Study design: Articles were chosen based on a Medline and EMBASE searches (1990-2005) with no language restrictions. An ongoing case-control study conducted in Nashville, TN, was also included. Articles evaluating the association between G-308>A and preterm birth were screened according to specific inclusion criteria. Meta-analysis was performed by using a random effect model. Association between maternal -308 genotype and AF-TNF-α concentration was determined by sandwich immunoassays. Results: Titles and abstracts of 6851 citations identified through the search were screened. Including our own study, a total of 7 studies were included for meta-analysis. Only 2 reported a statistically significant increased risk based on -308 genotype. Meta-analysis of the case-control studies on a pooled dataset (a total of 1846 subjects, 638 cases, and 1208 controls) showed no significant association between the -308 genotype and the risk of preterm birth (odds ratio [OR] 1.41; CI 0.90-2.19). A nonsignificant increase of AF TNF-α concentration was demonstrated with the GG genotype in cases compared with the presence of allele A. Conclusion: Meta-analysis of available evidence documented no statistically significant association between a single nucleotide polymorphism in the TNF-α gene (G-308>A) and preterm birth. Analyses of AF-TNF-α concentration demonstrated no increase in TNF-α in the presence of the minor allele (A).These results suggest that this single nucleotide polymorphism does not independently associate strongly with preterm birth.

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