Abstract
We estimated the reflection (σ) and filtration coefficients (K(f)) in a chronic sheep lung lymphatic preparation after smoke inhalation. Group I (n = 7) sheep were insufflated with cotton smoke and group II animals (n = 5) with room air. After inhalation injury, the lung lymph flow increased nearly four times the baseline value by 24 h after injury. There was a concomitant reduction of σ (0.81 ± 0.02 to 0.64 ± 0.02) and elevation of K(f) (0.020 ± 0.002 to 0.042 ± 0.009 ml · min-1 · mmHg-1); pulmonary capillary pressure was also elevated (13 ± 1 to 17 ± 1 mmHg). By 48 h postinjury, σ and K(f) returned toward baseline but pulmonary capillary pressure was still elevated. We determined that 34% of the increase in capillary filtration was attributable to increased capillary pressure and 66% to increased permeability 24 h after inhalation, but 48 h after injury, 75% of the increase in capillary filtration was attributable to increased capillary pressure and 25% to increased permeability. We conclude that the lung edema formation following smoke inhalation is the result of marked increases in both capillary pressure and permeability.
Original language | English (US) |
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Pages (from-to) | 1403-1408 |
Number of pages | 6 |
Journal | Journal of Applied Physiology |
Volume | 71 |
Issue number | 4 |
DOIs | |
State | Published - 1991 |
Keywords
- filtration coefficient
- pulmonary capillary pressure
- pulmonary venous occluders
- reflection coefficient
ASJC Scopus subject areas
- Physiology
- Physiology (medical)