Analysis of the potential for transfer of lipoprotein-cholesterol across the human placenta

C. R. Parker, T. Deahl, P. Drewry, Gary Hankins

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We sought to determine whether evidence exists for the contribution of maternal plasma cholesterol to the fetal plasma cholesterol pool. We found maternal lipoprotein-cholesterol levels at the time of delivery to be significantly higher than those in mixed umbilical cord plasma. The maternal plasma levels of total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol were not correlated to fetal plasma levels of these lipoproteins. There was a weak, but statistically significant, positive correlation between maternal and fetal plasma levels of very low-density lipoprotein (VLDL)-cholesterol. Also, we found a highly significant difference between the levels of HDL-, LDL-, and total cholesterol in umbilical venous and umbilical arterial plasma; venous levels being 7.7-12.8% higher than those in arterial plasma. These data are suggestive that cholesterol derived from maternal plasma can be delivered across the placenta to the fetal compartment in normal pregnancies at term. The contribution of such cholesterol to the fetal plasma cholesterol pool, however, appears to be of minimal quantitative importance in term newborns of women experiencing uncomplicated pregnancies.

Original languageEnglish (US)
Pages (from-to)289-295
Number of pages7
JournalEarly Human Development
Volume8
Issue number3-4
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Placenta
Cholesterol
Mothers
Umbilicus
LDL Cholesterol
lipoprotein cholesterol
VLDL Cholesterol
Pregnancy
Umbilical Cord
HDL Lipoproteins
HDL Cholesterol
Lipoproteins
Newborn Infant

Keywords

  • human placenta
  • lipoprotein-cholesterol transport

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Analysis of the potential for transfer of lipoprotein-cholesterol across the human placenta. / Parker, C. R.; Deahl, T.; Drewry, P.; Hankins, Gary.

In: Early Human Development, Vol. 8, No. 3-4, 1983, p. 289-295.

Research output: Contribution to journalArticle

Parker, C. R. ; Deahl, T. ; Drewry, P. ; Hankins, Gary. / Analysis of the potential for transfer of lipoprotein-cholesterol across the human placenta. In: Early Human Development. 1983 ; Vol. 8, No. 3-4. pp. 289-295.
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