Analyzing the cryptome: Uncovering secret sequences

Parimal Samir; Andrew J. Link

doi:10.1208/s12248-011-9252-2

Analyzing the cryptome: Uncovering secret sequences

Parimal Samir, Andrew J. Link

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

The mammalian cryptome consists of bioactive peptides generated by the proteolysis of precursor proteins. It is speculated that the cryptide repertoire increases the complexity of the proteome by an order of magnitude. Cryptides have been found to function in a wide range of processes including neuronal signaling, antigen presentation, and the inflammatory response. Due to their potential as therapeutic agents, there has been an increasing interest in studying cryptides. In this review, we discuss different approaches for discovering these hidden peptides and how proteomic tools can be utilized to aid in their identification and characterization.

Original language	English (US)
Pages (from-to)	152-158
Number of pages	7
Journal	AAPS Journal
Volume	13
Issue number	2
DOIs	https://doi.org/10.1208/s12248-011-9252-2
State	Published - Jun 2011
Externally published	Yes

Keywords

bioactive peptides
cryptides
cryptome
cryptomics
mass spectrometry-based proteomics

ASJC Scopus subject areas

Pharmaceutical Science

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10.1208/s12248-011-9252-2

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title = "Analyzing the cryptome: Uncovering secret sequences",

abstract = "The mammalian cryptome consists of bioactive peptides generated by the proteolysis of precursor proteins. It is speculated that the cryptide repertoire increases the complexity of the proteome by an order of magnitude. Cryptides have been found to function in a wide range of processes including neuronal signaling, antigen presentation, and the inflammatory response. Due to their potential as therapeutic agents, there has been an increasing interest in studying cryptides. In this review, we discuss different approaches for discovering these hidden peptides and how proteomic tools can be utilized to aid in their identification and characterization.",

keywords = "bioactive peptides, cryptides, cryptome, cryptomics, mass spectrometry-based proteomics",

author = "Parimal Samir and Link, {Andrew J.}",

note = "Funding Information: We acknowledge Elizabeth M. Link for helpful comments and suggestions in the preparation of this manuscript. P.S. and A.J.L. were supported by NIH grant GM64779.",

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AU - Link, Andrew J.

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N2 - The mammalian cryptome consists of bioactive peptides generated by the proteolysis of precursor proteins. It is speculated that the cryptide repertoire increases the complexity of the proteome by an order of magnitude. Cryptides have been found to function in a wide range of processes including neuronal signaling, antigen presentation, and the inflammatory response. Due to their potential as therapeutic agents, there has been an increasing interest in studying cryptides. In this review, we discuss different approaches for discovering these hidden peptides and how proteomic tools can be utilized to aid in their identification and characterization.

AB - The mammalian cryptome consists of bioactive peptides generated by the proteolysis of precursor proteins. It is speculated that the cryptide repertoire increases the complexity of the proteome by an order of magnitude. Cryptides have been found to function in a wide range of processes including neuronal signaling, antigen presentation, and the inflammatory response. Due to their potential as therapeutic agents, there has been an increasing interest in studying cryptides. In this review, we discuss different approaches for discovering these hidden peptides and how proteomic tools can be utilized to aid in their identification and characterization.

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KW - cryptome

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KW - mass spectrometry-based proteomics

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Analyzing the cryptome: Uncovering secret sequences

Abstract

Keywords

ASJC Scopus subject areas

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