Anaphylactic reactions following infusion of factor VIII in a patient with classic hemophilia

Richard E. Helmer, Jack B. Alperin, John W. Yunginger, J. Andrew Grant

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23 Scopus citations


A 28 year old white man with hemophilia A had, for several years, been successfully maintained on a home care program utilizing self-administration of factor VIII concentrates, but one such infusion resulted in severe anaphylaxis. An immunoglobulin E (IgE)-mediated hypersensitivity response was demonstrated by (1) the release of histamine from the patient's basophils in vitro upon challenge with several different lots of factor VIII concentrate; (2) immediate cutaneous response to commercial factor VIII, factor IX and cryoprecipitate; and (3) measurement of IgE antibodies against a commercial factor VIII preparation. A subsequent life-threatening hemorrhage required cautious infusion of another commercial lot of factor VIII concentrate. Despite pretreatment with antiallergic drugs and attempted desensitization, a moderately severe anaphylactic reaction was observed.

Original languageEnglish (US)
Pages (from-to)953-957
Number of pages5
JournalThe American Journal of Medicine
Issue number6
StatePublished - Dec 1980
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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