@article{a52013c528c64495959c9a2f33ef4a32,
title = "Anaphylactic reactions following infusion of factor VIII in a patient with classic hemophilia",
abstract = "A 28 year old white man with hemophilia A had, for several years, been successfully maintained on a home care program utilizing self-administration of factor VIII concentrates, but one such infusion resulted in severe anaphylaxis. An immunoglobulin E (IgE)-mediated hypersensitivity response was demonstrated by (1) the release of histamine from the patient's basophils in vitro upon challenge with several different lots of factor VIII concentrate; (2) immediate cutaneous response to commercial factor VIII, factor IX and cryoprecipitate; and (3) measurement of IgE antibodies against a commercial factor VIII preparation. A subsequent life-threatening hemorrhage required cautious infusion of another commercial lot of factor VIII concentrate. Despite pretreatment with antiallergic drugs and attempted desensitization, a moderately severe anaphylactic reaction was observed.",
author = "Helmer, {Richard E.} and Alperin, {Jack B.} and Yunginger, {John W.} and {Andrew Grant}, J.",
note = "Funding Information: RICHARD E. HELMER, III, M.D.* JACK B. ALPERIN, M.D. Galveston, Texas JOHN W. YUNGINGER, M.D. Rochester, Minnesota J. ANDREW GRANT, M.D. Galveston, Texas From the Divisions of Hematology-Oncologya nd Allergy, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas; and the Research Laboratory for Allergic Diseases, Mayo Clinic, Rochester, Minnesota. These studies were supported by Allergic Disease Academic Awards A100107 (J.W.Y.J and AI 00110 \[\].A.G.f)r om the National Institute of Allergy and Infectious Diseases and also by the General Clinic Research Center Program, National Institutes of Health (RR-73). Requests for reprints should be addressed to Dr. I. Andrew Grant, University of Texas Medical Branch, Clinical Sciences 405, Galveston, TX 77550. Manuscript accepted January 7, 1980. * Present address: 4204 Lostridge Drive, Austin, TX 78731.",
year = "1980",
month = dec,
doi = "10.1016/S0002-9343(80)80026-X",
language = "English (US)",
volume = "69",
pages = "953--957",
journal = "The American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "6",
}