Anaphylactic reactions following infusion of factor VIII in a patient with classic hemophilia

Richard E. Helmer; Jack B. Alperin; John W. Yunginger; J. Andrew Grant

doi:10.1016/S0002-9343(80)80026-X

Anaphylactic reactions following infusion of factor VIII in a patient with classic hemophilia

Richard E. Helmer
, Jack B. Alperin
, John W. Yunginger
, J. Andrew Grant

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A 28 year old white man with hemophilia A had, for several years, been successfully maintained on a home care program utilizing self-administration of factor VIII concentrates, but one such infusion resulted in severe anaphylaxis. An immunoglobulin E (IgE)-mediated hypersensitivity response was demonstrated by (1) the release of histamine from the patient's basophils in vitro upon challenge with several different lots of factor VIII concentrate; (2) immediate cutaneous response to commercial factor VIII, factor IX and cryoprecipitate; and (3) measurement of IgE antibodies against a commercial factor VIII preparation. A subsequent life-threatening hemorrhage required cautious infusion of another commercial lot of factor VIII concentrate. Despite pretreatment with antiallergic drugs and attempted desensitization, a moderately severe anaphylactic reaction was observed.

Original language	English (US)
Pages (from-to)	953-957
Number of pages	5
Journal	The American Journal of Medicine
Volume	69
Issue number	6
DOIs	https://doi.org/10.1016/S0002-9343(80)80026-X
State	Published - Dec 1980
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/S0002-9343(80)80026-X

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@article{a52013c528c64495959c9a2f33ef4a32,

title = "Anaphylactic reactions following infusion of factor VIII in a patient with classic hemophilia",

abstract = "A 28 year old white man with hemophilia A had, for several years, been successfully maintained on a home care program utilizing self-administration of factor VIII concentrates, but one such infusion resulted in severe anaphylaxis. An immunoglobulin E (IgE)-mediated hypersensitivity response was demonstrated by (1) the release of histamine from the patient's basophils in vitro upon challenge with several different lots of factor VIII concentrate; (2) immediate cutaneous response to commercial factor VIII, factor IX and cryoprecipitate; and (3) measurement of IgE antibodies against a commercial factor VIII preparation. A subsequent life-threatening hemorrhage required cautious infusion of another commercial lot of factor VIII concentrate. Despite pretreatment with antiallergic drugs and attempted desensitization, a moderately severe anaphylactic reaction was observed.",

author = "Helmer, \{Richard E.\} and Alperin, \{Jack B.\} and Yunginger, \{John W.\} and \{Andrew Grant\}, J.",

note = "Funding Information: RICHARD E. HELMER, III, M.D.* JACK B. ALPERIN, M.D. Galveston, Texas JOHN W. YUNGINGER, M.D. Rochester, Minnesota J. ANDREW GRANT, M.D. Galveston, Texas From the Divisions of Hematology-Oncologya nd Allergy, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas; and the Research Laboratory for Allergic Diseases, Mayo Clinic, Rochester, Minnesota. These studies were supported by Allergic Disease Academic Awards A100107 (J.W.Y.J and AI 00110 \textbackslash{}[\textbackslash{}].A.G.f)r om the National Institute of Allergy and Infectious Diseases and also by the General Clinic Research Center Program, National Institutes of Health (RR-73). Requests for reprints should be addressed to Dr. I. Andrew Grant, University of Texas Medical Branch, Clinical Sciences 405, Galveston, TX 77550. Manuscript accepted January 7, 1980. * Present address: 4204 Lostridge Drive, Austin, TX 78731.",

year = "1980",

month = dec,

doi = "10.1016/S0002-9343(80)80026-X",

language = "English (US)",

volume = "69",

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journal = "The American Journal of Medicine",

issn = "0002-9343",

publisher = "Elsevier Inc.",

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AU - Andrew Grant, J.

N1 - Funding Information: RICHARD E. HELMER, III, M.D.* JACK B. ALPERIN, M.D. Galveston, Texas JOHN W. YUNGINGER, M.D. Rochester, Minnesota J. ANDREW GRANT, M.D. Galveston, Texas From the Divisions of Hematology-Oncologya nd Allergy, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas; and the Research Laboratory for Allergic Diseases, Mayo Clinic, Rochester, Minnesota. These studies were supported by Allergic Disease Academic Awards A100107 (J.W.Y.J and AI 00110 \[\].A.G.f)r om the National Institute of Allergy and Infectious Diseases and also by the General Clinic Research Center Program, National Institutes of Health (RR-73). Requests for reprints should be addressed to Dr. I. Andrew Grant, University of Texas Medical Branch, Clinical Sciences 405, Galveston, TX 77550. Manuscript accepted January 7, 1980. * Present address: 4204 Lostridge Drive, Austin, TX 78731.

PY - 1980/12

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N2 - A 28 year old white man with hemophilia A had, for several years, been successfully maintained on a home care program utilizing self-administration of factor VIII concentrates, but one such infusion resulted in severe anaphylaxis. An immunoglobulin E (IgE)-mediated hypersensitivity response was demonstrated by (1) the release of histamine from the patient's basophils in vitro upon challenge with several different lots of factor VIII concentrate; (2) immediate cutaneous response to commercial factor VIII, factor IX and cryoprecipitate; and (3) measurement of IgE antibodies against a commercial factor VIII preparation. A subsequent life-threatening hemorrhage required cautious infusion of another commercial lot of factor VIII concentrate. Despite pretreatment with antiallergic drugs and attempted desensitization, a moderately severe anaphylactic reaction was observed.

AB - A 28 year old white man with hemophilia A had, for several years, been successfully maintained on a home care program utilizing self-administration of factor VIII concentrates, but one such infusion resulted in severe anaphylaxis. An immunoglobulin E (IgE)-mediated hypersensitivity response was demonstrated by (1) the release of histamine from the patient's basophils in vitro upon challenge with several different lots of factor VIII concentrate; (2) immediate cutaneous response to commercial factor VIII, factor IX and cryoprecipitate; and (3) measurement of IgE antibodies against a commercial factor VIII preparation. A subsequent life-threatening hemorrhage required cautious infusion of another commercial lot of factor VIII concentrate. Despite pretreatment with antiallergic drugs and attempted desensitization, a moderately severe anaphylactic reaction was observed.

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Anaphylactic reactions following infusion of factor VIII in a patient with classic hemophilia

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