Anatomic study of the pulmonary artery as a conduit for an artificial lung

D. D. Harper, S. K. Alpard, D. J. Deyo, S. D. Lick, D. L. Traber, J. B. Zwischenberger

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Our group is developing an artificial lung (AL) as a bridge to recovery or transplant. Utilizing a pulmonary artery (PA)-to-PA or PA-to-left atrial (LA) shunt, any anatomic variant to the common PA will affect AL flow. We evaluated the sheep PA for the presence or absence of a septum or other anatomic variant, which may divert or increase resistance to PA blood flow. Adult Suffolk ewes (N=21,30-43 kg) were sedated and euthanized. The heart and lungs were removed en bloc through a median sternotomy. The common PA was isolated, beginning at the sinus of Valsalva, and ending 2 cm past the primary bifurcation. The ligamentum arteriosum was identified and checked for patency. The PA was incised from the sinus of Valsalva to the terminus of the left and right pulmonary arteries. The circumference of the common PA midway between the sinus of Valsalva and the primary bifurcation, and the length of the common PA from the sinus of Valsalva to the primary bifurcation was measured. All pulmonary arteries were void of any form of septation. The ligamentum arteriosum in each PA was not patent. The length of the PA from the sinus of Valsalva to the observed primary bifurcation was 5.0 cm and the diameter was 2.0 cm. (d = circumference / Pi). We conclude the PA is not a source of increased resistance and is a suitable conduit for AL implantation in the PA-PA or PA-LA configuration.

    Original languageEnglish (US)
    Pages (from-to)184
    Number of pages1
    JournalASAIO Journal
    Volume46
    Issue number2
    StatePublished - Mar 2000

    Fingerprint

    Transplants
    Pulmonary Artery
    Blood
    Recovery
    Lung
    Sinus of Valsalva
    Sternotomy

    ASJC Scopus subject areas

    • Biophysics
    • Bioengineering

    Cite this

    Harper, D. D., Alpard, S. K., Deyo, D. J., Lick, S. D., Traber, D. L., & Zwischenberger, J. B. (2000). Anatomic study of the pulmonary artery as a conduit for an artificial lung. ASAIO Journal, 46(2), 184.

    Anatomic study of the pulmonary artery as a conduit for an artificial lung. / Harper, D. D.; Alpard, S. K.; Deyo, D. J.; Lick, S. D.; Traber, D. L.; Zwischenberger, J. B.

    In: ASAIO Journal, Vol. 46, No. 2, 03.2000, p. 184.

    Research output: Contribution to journalArticle

    Harper, DD, Alpard, SK, Deyo, DJ, Lick, SD, Traber, DL & Zwischenberger, JB 2000, 'Anatomic study of the pulmonary artery as a conduit for an artificial lung', ASAIO Journal, vol. 46, no. 2, pp. 184.
    Harper DD, Alpard SK, Deyo DJ, Lick SD, Traber DL, Zwischenberger JB. Anatomic study of the pulmonary artery as a conduit for an artificial lung. ASAIO Journal. 2000 Mar;46(2):184.
    Harper, D. D. ; Alpard, S. K. ; Deyo, D. J. ; Lick, S. D. ; Traber, D. L. ; Zwischenberger, J. B. / Anatomic study of the pulmonary artery as a conduit for an artificial lung. In: ASAIO Journal. 2000 ; Vol. 46, No. 2. pp. 184.
    @article{c4d730c602f340d591a4cc31f2cbd567,
    title = "Anatomic study of the pulmonary artery as a conduit for an artificial lung",
    abstract = "Our group is developing an artificial lung (AL) as a bridge to recovery or transplant. Utilizing a pulmonary artery (PA)-to-PA or PA-to-left atrial (LA) shunt, any anatomic variant to the common PA will affect AL flow. We evaluated the sheep PA for the presence or absence of a septum or other anatomic variant, which may divert or increase resistance to PA blood flow. Adult Suffolk ewes (N=21,30-43 kg) were sedated and euthanized. The heart and lungs were removed en bloc through a median sternotomy. The common PA was isolated, beginning at the sinus of Valsalva, and ending 2 cm past the primary bifurcation. The ligamentum arteriosum was identified and checked for patency. The PA was incised from the sinus of Valsalva to the terminus of the left and right pulmonary arteries. The circumference of the common PA midway between the sinus of Valsalva and the primary bifurcation, and the length of the common PA from the sinus of Valsalva to the primary bifurcation was measured. All pulmonary arteries were void of any form of septation. The ligamentum arteriosum in each PA was not patent. The length of the PA from the sinus of Valsalva to the observed primary bifurcation was 5.0 cm and the diameter was 2.0 cm. (d = circumference / Pi). We conclude the PA is not a source of increased resistance and is a suitable conduit for AL implantation in the PA-PA or PA-LA configuration.",
    author = "Harper, {D. D.} and Alpard, {S. K.} and Deyo, {D. J.} and Lick, {S. D.} and Traber, {D. L.} and Zwischenberger, {J. B.}",
    year = "2000",
    month = "3",
    language = "English (US)",
    volume = "46",
    pages = "184",
    journal = "ASAIO Journal",
    issn = "1058-2916",
    publisher = "Lippincott Williams and Wilkins",
    number = "2",

    }

    TY - JOUR

    T1 - Anatomic study of the pulmonary artery as a conduit for an artificial lung

    AU - Harper, D. D.

    AU - Alpard, S. K.

    AU - Deyo, D. J.

    AU - Lick, S. D.

    AU - Traber, D. L.

    AU - Zwischenberger, J. B.

    PY - 2000/3

    Y1 - 2000/3

    N2 - Our group is developing an artificial lung (AL) as a bridge to recovery or transplant. Utilizing a pulmonary artery (PA)-to-PA or PA-to-left atrial (LA) shunt, any anatomic variant to the common PA will affect AL flow. We evaluated the sheep PA for the presence or absence of a septum or other anatomic variant, which may divert or increase resistance to PA blood flow. Adult Suffolk ewes (N=21,30-43 kg) were sedated and euthanized. The heart and lungs were removed en bloc through a median sternotomy. The common PA was isolated, beginning at the sinus of Valsalva, and ending 2 cm past the primary bifurcation. The ligamentum arteriosum was identified and checked for patency. The PA was incised from the sinus of Valsalva to the terminus of the left and right pulmonary arteries. The circumference of the common PA midway between the sinus of Valsalva and the primary bifurcation, and the length of the common PA from the sinus of Valsalva to the primary bifurcation was measured. All pulmonary arteries were void of any form of septation. The ligamentum arteriosum in each PA was not patent. The length of the PA from the sinus of Valsalva to the observed primary bifurcation was 5.0 cm and the diameter was 2.0 cm. (d = circumference / Pi). We conclude the PA is not a source of increased resistance and is a suitable conduit for AL implantation in the PA-PA or PA-LA configuration.

    AB - Our group is developing an artificial lung (AL) as a bridge to recovery or transplant. Utilizing a pulmonary artery (PA)-to-PA or PA-to-left atrial (LA) shunt, any anatomic variant to the common PA will affect AL flow. We evaluated the sheep PA for the presence or absence of a septum or other anatomic variant, which may divert or increase resistance to PA blood flow. Adult Suffolk ewes (N=21,30-43 kg) were sedated and euthanized. The heart and lungs were removed en bloc through a median sternotomy. The common PA was isolated, beginning at the sinus of Valsalva, and ending 2 cm past the primary bifurcation. The ligamentum arteriosum was identified and checked for patency. The PA was incised from the sinus of Valsalva to the terminus of the left and right pulmonary arteries. The circumference of the common PA midway between the sinus of Valsalva and the primary bifurcation, and the length of the common PA from the sinus of Valsalva to the primary bifurcation was measured. All pulmonary arteries were void of any form of septation. The ligamentum arteriosum in each PA was not patent. The length of the PA from the sinus of Valsalva to the observed primary bifurcation was 5.0 cm and the diameter was 2.0 cm. (d = circumference / Pi). We conclude the PA is not a source of increased resistance and is a suitable conduit for AL implantation in the PA-PA or PA-LA configuration.

    UR - http://www.scopus.com/inward/record.url?scp=0034159690&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0034159690&partnerID=8YFLogxK

    M3 - Article

    VL - 46

    SP - 184

    JO - ASAIO Journal

    JF - ASAIO Journal

    SN - 1058-2916

    IS - 2

    ER -