ANCA-associated vasculitis and severe proximal muscle weakness

Jordan S. Dutcher, Albert Bui, Tochukwu A. Ibe, Goyal Umadat, Eugene P. Harper, Erik H. Middlebrooks, Michael M. Mohseni, Michael B. Phillips

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


ANCA-associated vasculitis is a multiorgan autoimmune inflammatory disease that has a heterogeneous clinical presentation. Our case report provides additional evidence supporting the association between granulomatosis with polyangiitis and myositis. In our patient with proximal muscle weakness and pain, a normal creatine kinase and lack of antibodies to muscular fiber units ruled out primary myositis. Distinct magnetic resonance imaging of the brain within the deep gray matter in addition to positive serologies were consistent with a diagnosis of granulomatosis with polyangiitis. ANCA-associated vasculitis, specifically granulomatosis with polyangiitis, may be overlooked if musculoskeletal manifestations are the presenting symptoms. Prompt and aggressive treatment prevented this patient from experiencing multiorgan failure.

Original languageEnglish (US)
Pages (from-to)384-386
Number of pages3
JournalBaylor University Medical Center Proceedings
Issue number3
StatePublished - 2021
Externally publishedYes


  • ANCA
  • granulomatosis with polyangiitis
  • myositis
  • proximal muscle weakness
  • vasculitis

ASJC Scopus subject areas

  • General Medicine


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