Androgen insensitivity in man: evidence for genetic heterogeneity

J. A. Amrhein, W. J. Meyer, H. W.C.J. Jones andMigeon

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

The authors have studied ten phenotypically similar patients wtih complete androgen insensitivity. All of the patients tested had significantly elevated serum luteinizing hormone and plasma androgens within or above the normal adult male range. On the basis of specific dihydrotestosterone binding by skin fibroblasts, we identified two subgroups. Six patients from five different families had undetectable dihydrotestosterone binding, while four patients from two families had normal binding activity. Our results indicate that within the clinical syndrome of androgen insensitivity there are at least two distinct genetic variants. These variants may result from allelic mutations of the same X linked gene specifying the dihydrotestosterone receptor or, alternatively, from mutations of separate genes both being essential for androgen action in responsive cells.

Original languageEnglish (US)
Pages (from-to)891-894
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume73
Issue number3
DOIs
StatePublished - Jan 1 1976

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