Androgen therapy induces muscle protein anabolism in older women

Melinda Sheffield-Moore, Douglas Paddon-Jones, Shanon L. Casperson, Charles Gilkison, Elena Volpi, Steven Wolf, Jie Jiang, Judah I. Rosenblatt, Randall Urban

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Context: Normal healthy men and women undergo a gradual loss of skeletal muscle mass and strength with advancing age. While androgens are protein anabolic in older men, the metabolic effects in older women are poorly understood. Objective and Design: The objective of this study was to determine whether oral administration of a synthetic derivative of testosterone [oxandrolone, Oxandrin (OX)] (7.5 mg orally twice daily for 14 d) to five older women (age, 65 ± 2 yr) would enhance skeletal muscle anabolic biomarkers including mixed muscle fractional synthetic rate (FSR), net phenylalanine balance, androgen receptor, and IGF-I protein expression at d 0, 5, and 14 of treatment. As a positive control, seven older men were examined after 14 d of OX (10 mg orally twice daily). Setting: The study was performed at the General Clinical Research Center. Results: Fourteen days of OX significantly increased skeletal muscle FSR in older women (d 0, 0.073 ± 0.006 vs. d 5, 0.092 ± 0.006 vs. d 14, 0.115 ± 0.007%/h) (P < 0.05, d 0 vs. d 14). Conversely, OX stimulated FSR in older men after only 5 d (d 0, 0.061 ± 0.003 vs. d 5, 0.101 ± 0.01 vs. d 14, 0.084 ± 0.01%/h) (P < 0.05, d 0 vs. d 5). Androgen receptor expression was significantly increased in older men by d 14, but had not increased in older women. No change was noted in IGF-I expression in either group. We conclude that the skeletal muscle of older women and men responds to androgen administration, although the time course of anabolism appears to be gender specific.

Original languageEnglish (US)
Pages (from-to)3844-3849
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume91
Issue number10
DOIs
StatePublished - Oct 2006

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Oxandrolone
Muscle Proteins
Androgens
Muscle
Skeletal Muscle
Androgen Receptors
Insulin-Like Growth Factor I
Therapeutics
Biomarkers
Phenylalanine
Muscle Strength
Testosterone
Proteins
Oral Administration
Derivatives
Muscles
Research

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Androgen therapy induces muscle protein anabolism in older women. / Sheffield-Moore, Melinda; Paddon-Jones, Douglas; Casperson, Shanon L.; Gilkison, Charles; Volpi, Elena; Wolf, Steven; Jiang, Jie; Rosenblatt, Judah I.; Urban, Randall.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 91, No. 10, 10.2006, p. 3844-3849.

Research output: Contribution to journalArticle

Sheffield-Moore, Melinda ; Paddon-Jones, Douglas ; Casperson, Shanon L. ; Gilkison, Charles ; Volpi, Elena ; Wolf, Steven ; Jiang, Jie ; Rosenblatt, Judah I. ; Urban, Randall. / Androgen therapy induces muscle protein anabolism in older women. In: Journal of Clinical Endocrinology and Metabolism. 2006 ; Vol. 91, No. 10. pp. 3844-3849.
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abstract = "Context: Normal healthy men and women undergo a gradual loss of skeletal muscle mass and strength with advancing age. While androgens are protein anabolic in older men, the metabolic effects in older women are poorly understood. Objective and Design: The objective of this study was to determine whether oral administration of a synthetic derivative of testosterone [oxandrolone, Oxandrin (OX)] (7.5 mg orally twice daily for 14 d) to five older women (age, 65 ± 2 yr) would enhance skeletal muscle anabolic biomarkers including mixed muscle fractional synthetic rate (FSR), net phenylalanine balance, androgen receptor, and IGF-I protein expression at d 0, 5, and 14 of treatment. As a positive control, seven older men were examined after 14 d of OX (10 mg orally twice daily). Setting: The study was performed at the General Clinical Research Center. Results: Fourteen days of OX significantly increased skeletal muscle FSR in older women (d 0, 0.073 ± 0.006 vs. d 5, 0.092 ± 0.006 vs. d 14, 0.115 ± 0.007{\%}/h) (P < 0.05, d 0 vs. d 14). Conversely, OX stimulated FSR in older men after only 5 d (d 0, 0.061 ± 0.003 vs. d 5, 0.101 ± 0.01 vs. d 14, 0.084 ± 0.01{\%}/h) (P < 0.05, d 0 vs. d 5). Androgen receptor expression was significantly increased in older men by d 14, but had not increased in older women. No change was noted in IGF-I expression in either group. We conclude that the skeletal muscle of older women and men responds to androgen administration, although the time course of anabolism appears to be gender specific.",
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