Angiographic analysis of animal model aneurysms treated with novel polyurethane asymmetric vascular stent (P-AVS): Feasibility study

Ciprian N. Ionita, Andreea Dohatcu, Andrey Sinelnikov, Jason Sherman, Christos Keleshis, Ann M. Paciorek, K. R. Hoffmann, D. R. Bednarek, S. Rudin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Citations (Scopus)

Abstract

Image-guided endovascular intervention (EIGI), using new flow modifying endovascular devices for intracranial aneurysm treatment is an active area of stroke research. The new polyurethane-asymmetric vascular stent (P-AVS), a vascular stent partially covered with a polyurethane-based patch, is used to cover the aneurysm neck, thus occluding flow into the aneurysm. This study involves angiographic imaging of partially covered aneurysm orifices. This particular situation could occur when the vascular geometry does not allow full aneurysm coverage. Four standard invivo rabbit-model aneurysms were investigated; two had stent patches placed over the distal region of the aneurysm orifice while the other two had stent patches placed over the proximal region of the aneurysm orifice. Angiographic analysis was used to evaluate aneurysm blood flow before and immediately after stenting and at four-week follow-up. The treatment results were also evaluated using histology on the aneurysm dome and electron microscopy on the aneurysm neck. Post-stenting angiographic flow analysis revealed aneurysmal flow reduction in all cases with faster flow in the distally-covered case and very slow flow and prolonged pooling for proximal-coverage. At follow-up,proximally-covered aneurysms showed full dome occlusion. The electron microscopy showed a remnant neck in both distally-placed stent cases but complete coverage in the proximally-placed stent cases. Thus, direct flow (impingement jet) removal from the aneurysm dome, as indicated by angiograms in the proximally-covered case, was sufficient to cause full aneurysm healing in four weeks; however, aneurysm healing was not complete for the distally-covered case.These results support further investigations into the treatment of aneurysms by flow-modification using partial aneurysm- orifice coverage.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
Volume7262
DOIs
StatePublished - 2009
Externally publishedYes
EventMedical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States
Duration: Feb 8 2009Feb 10 2009

Other

OtherMedical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/8/092/10/09

Fingerprint

animal models
Stents
Polyurethanes
Feasibility Studies
Aneurysm
Blood Vessels
Animals
Animal Models
Orifices
orifices
Domes
domes
Electron microscopy
healing
electron microscopy
Histology
jet impingement
histology
occlusion
rabbits

Keywords

  • AnEurysm treatment
  • Angiography
  • Asymmetric vascular stent
  • AVS
  • Flow modification
  • Hemodynamics

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Ionita, C. N., Dohatcu, A., Sinelnikov, A., Sherman, J., Keleshis, C., Paciorek, A. M., ... Rudin, S. (2009). Angiographic analysis of animal model aneurysms treated with novel polyurethane asymmetric vascular stent (P-AVS): Feasibility study. In Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging (Vol. 7262). [72621H] https://doi.org/10.1117/12.812628

Angiographic analysis of animal model aneurysms treated with novel polyurethane asymmetric vascular stent (P-AVS) : Feasibility study. / Ionita, Ciprian N.; Dohatcu, Andreea; Sinelnikov, Andrey; Sherman, Jason; Keleshis, Christos; Paciorek, Ann M.; Hoffmann, K. R.; Bednarek, D. R.; Rudin, S.

Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 7262 2009. 72621H.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ionita, CN, Dohatcu, A, Sinelnikov, A, Sherman, J, Keleshis, C, Paciorek, AM, Hoffmann, KR, Bednarek, DR & Rudin, S 2009, Angiographic analysis of animal model aneurysms treated with novel polyurethane asymmetric vascular stent (P-AVS): Feasibility study. in Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging. vol. 7262, 72621H, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, Lake Buena Vista, FL, United States, 2/8/09. https://doi.org/10.1117/12.812628
Ionita CN, Dohatcu A, Sinelnikov A, Sherman J, Keleshis C, Paciorek AM et al. Angiographic analysis of animal model aneurysms treated with novel polyurethane asymmetric vascular stent (P-AVS): Feasibility study. In Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 7262. 2009. 72621H https://doi.org/10.1117/12.812628
Ionita, Ciprian N. ; Dohatcu, Andreea ; Sinelnikov, Andrey ; Sherman, Jason ; Keleshis, Christos ; Paciorek, Ann M. ; Hoffmann, K. R. ; Bednarek, D. R. ; Rudin, S. / Angiographic analysis of animal model aneurysms treated with novel polyurethane asymmetric vascular stent (P-AVS) : Feasibility study. Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 7262 2009.
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