Animal challenge models of henipavirus infection and pathogenesis

Thomas W. Geisbert, Heinz Feldmann, Christopher C. Broder

Research output: Chapter in Book/Report/Conference proceedingChapter

47 Scopus citations

Abstract

The henipaviruses, Hendra virus (HeV), and Nipah virus (NiV), are enigmatic emerging pathogens that causes severe and often fatal neurologic and/or respiratory disease in both animals and humans. Amongst people, case fatality rates range between 40 and 75% and there are no vaccines or treatments approved for human use. A number of species of animals including guinea pigs, hamsters, cats, ferrets, pigs, and African green monkeys have been employed as animal models of human henipavirus infection. Here, we review the development of animal models for henipavirus infection, discuss the pathology and pathogenesis of these models, and assess the utility of each model to recapitulate important aspects of henipavirus-mediated disease seen in humans.

Original languageEnglish (US)
Title of host publicationHenipavirus
Subtitle of host publicationEcology, Molecular Virology, and Pathogenesis
EditorsBenhur Lee, Paul Rota
Pages153-177
Number of pages25
DOIs
StatePublished - Nov 8 2012

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume359
ISSN (Print)0070-217X

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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  • Cite this

    Geisbert, T. W., Feldmann, H., & Broder, C. C. (2012). Animal challenge models of henipavirus infection and pathogenesis. In B. Lee, & P. Rota (Eds.), Henipavirus: Ecology, Molecular Virology, and Pathogenesis (pp. 153-177). (Current Topics in Microbiology and Immunology; Vol. 359). https://doi.org/10.1007/82-2012-208