Animal models for COVID-19

César Muñoz-Fontela; William E. Dowling; Simon G.P. Funnell; Pierre S. Gsell; A. Ximena Riveros-Balta; Randy A. Albrecht; Hanne Andersen; Ralph S. Baric; Miles W. Carroll; Marco Cavaleri; Chuan Qin; Ian Crozier; Kai Dallmeier; Leon de Waal; Emmie de Wit; Leen Delang; Erik Dohm; W. Paul Duprex; Darryl Falzarano; Courtney L. Finch; Matthew B. Frieman; Barney S. Graham; Lisa E. Gralinski; Kate Guilfoyle; Bart L. Haagmans; Geraldine A. Hamilton; Amy L. Hartman; Sander Herfst; Suzanne J.F. Kaptein; William B. Klimstra; Ivana Knezevic; Philip R. Krause; Jens H. Kuhn; Roger Le Grand; Mark G. Lewis; Wen Chun Liu; Pauline Maisonnasse; Anita K. McElroy; Vincent Munster; Nadia Oreshkova; Angela L. Rasmussen; Joana Rocha-Pereira; Barry Rockx; Estefanía Rodríguez; Thomas F. Rogers; Francisco J. Salguero; Michael Schotsaert; Koert J. Stittelaar; Hendrik Jan Thibaut; Chien Te Tseng; Júlia Vergara-Alert; Martin Beer; Trevor Brasel; Jasper F.W. Chan; Adolfo García-Sastre; Johan Neyts; Stanley Perlman; Douglas S. Reed; Juergen A. Richt; Chad J. Roy; Joaquim Segalés; Seshadri S. Vasan; Ana María Henao-Restrepo; Dan H. Barouch

doi:10.1038/s41586-020-2787-6

Animal models for COVID-19

César Muñoz-Fontela, William E. Dowling, Simon G.P. Funnell, Pierre S. Gsell, A. Ximena Riveros-Balta, Randy A. Albrecht, Hanne Andersen, Ralph S. Baric, Miles W. Carroll, Marco Cavaleri, Chuan Qin, Ian Crozier, Kai Dallmeier, Leon de Waal, Emmie de Wit, Leen Delang, Erik Dohm, W. Paul Duprex, Darryl Falzarano, Courtney L. FinchMatthew B. Frieman, Barney S. Graham, Lisa E. Gralinski, Kate Guilfoyle, Bart L. Haagmans, Geraldine A. Hamilton, Amy L. Hartman, Sander Herfst, Suzanne J.F. Kaptein, William B. Klimstra, Ivana Knezevic, Philip R. Krause, Jens H. Kuhn, Roger Le Grand, Mark G. Lewis, Wen Chun Liu, Pauline Maisonnasse, Anita K. McElroy, Vincent Munster, Nadia Oreshkova, Angela L. Rasmussen, Joana Rocha-Pereira, Barry Rockx, Estefanía Rodríguez, Thomas F. Rogers, Francisco J. Salguero, Michael Schotsaert, Koert J. Stittelaar, Hendrik Jan Thibaut, Chien Te Tseng, Júlia Vergara-Alert, Martin Beer, Trevor Brasel, Jasper F.W. Chan, Adolfo García-Sastre, Johan Neyts, Stanley Perlman, Douglas S. Reed, Juergen A. Richt, Chad J. Roy, Joaquim Segalés, Seshadri S. Vasan, Ana María Henao-Restrepo, Dan H. Barouch

Microbiology And Immunology

Research output: Contribution to journal › Review article › peer-review

591 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.

Original language	English (US)
Pages (from-to)	509-515
Number of pages	7
Journal	Nature
Volume	586
Issue number	7830
DOIs	https://doi.org/10.1038/s41586-020-2787-6
State	Published - Oct 22 2020

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Muñoz-Fontela, C., Dowling, W. E., Funnell, S. G. P., Gsell, P. S., Riveros-Balta, A. X., Albrecht, R. A., Andersen, H., Baric, R. S., Carroll, M. W., Cavaleri, M., Qin, C., Crozier, I., Dallmeier, K., de Waal, L., de Wit, E., Delang, L., Dohm, E., Duprex, W. P., Falzarano, D., ... Barouch, D. H. (2020). Animal models for COVID-19. Nature, 586(7830), 509-515. https://doi.org/10.1038/s41586-020-2787-6

Muñoz-Fontela, C, Dowling, WE, Funnell, SGP, Gsell, PS, Riveros-Balta, AX, Albrecht, RA, Andersen, H, Baric, RS, Carroll, MW, Cavaleri, M, Qin, C, Crozier, I, Dallmeier, K, de Waal, L, de Wit, E, Delang, L, Dohm, E, Duprex, WP, Falzarano, D, Finch, CL, Frieman, MB, Graham, BS, Gralinski, LE, Guilfoyle, K, Haagmans, BL, Hamilton, GA, Hartman, AL, Herfst, S, Kaptein, SJF, Klimstra, WB, Knezevic, I, Krause, PR, Kuhn, JH, Le Grand, R, Lewis, MG, Liu, WC, Maisonnasse, P, McElroy, AK, Munster, V, Oreshkova, N, Rasmussen, AL, Rocha-Pereira, J, Rockx, B, Rodríguez, E, Rogers, TF, Salguero, FJ, Schotsaert, M, Stittelaar, KJ, Thibaut, HJ, Tseng, CT, Vergara-Alert, J, Beer, M, Brasel, T, Chan, JFW, García-Sastre, A, Neyts, J, Perlman, S, Reed, DS, Richt, JA, Roy, CJ, Segalés, J, Vasan, SS, Henao-Restrepo, AM & Barouch, DH 2020, 'Animal models for COVID-19', Nature, vol. 586, no. 7830, pp. 509-515. https://doi.org/10.1038/s41586-020-2787-6

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title = "Animal models for COVID-19",

abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.",

author = "C{\'e}sar Mu{\~n}oz-Fontela and Dowling, {William E.} and Funnell, {Simon G.P.} and Gsell, {Pierre S.} and Riveros-Balta, {A. Ximena} and Albrecht, {Randy A.} and Hanne Andersen and Baric, {Ralph S.} and Carroll, {Miles W.} and Marco Cavaleri and Chuan Qin and Ian Crozier and Kai Dallmeier and {de Waal}, Leon and {de Wit}, Emmie and Leen Delang and Erik Dohm and Duprex, {W. Paul} and Darryl Falzarano and Finch, {Courtney L.} and Frieman, {Matthew B.} and Graham, {Barney S.} and Gralinski, {Lisa E.} and Kate Guilfoyle and Haagmans, {Bart L.} and Hamilton, {Geraldine A.} and Hartman, {Amy L.} and Sander Herfst and Kaptein, {Suzanne J.F.} and Klimstra, {William B.} and Ivana Knezevic and Krause, {Philip R.} and Kuhn, {Jens H.} and {Le Grand}, Roger and Lewis, {Mark G.} and Liu, {Wen Chun} and Pauline Maisonnasse and McElroy, {Anita K.} and Vincent Munster and Nadia Oreshkova and Rasmussen, {Angela L.} and Joana Rocha-Pereira and Barry Rockx and Estefan{\'i}a Rodr{\'i}guez and Rogers, {Thomas F.} and Salguero, {Francisco J.} and Michael Schotsaert and Stittelaar, {Koert J.} and Thibaut, {Hendrik Jan} and Tseng, {Chien Te} and J{\'u}lia Vergara-Alert and Martin Beer and Trevor Brasel and Chan, {Jasper F.W.} and Adolfo Garc{\'i}a-Sastre and Johan Neyts and Stanley Perlman and Reed, {Douglas S.} and Richt, {Juergen A.} and Roy, {Chad J.} and Joaquim Segal{\'e}s and Vasan, {Seshadri S.} and Henao-Restrepo, {Ana Mar{\'i}a} and Barouch, {Dan H.}",

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doi = "10.1038/s41586-020-2787-6",

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T1 - Animal models for COVID-19

AU - Muñoz-Fontela, César

AU - Dowling, William E.

AU - Funnell, Simon G.P.

AU - Gsell, Pierre S.

AU - Riveros-Balta, A. Ximena

AU - Albrecht, Randy A.

AU - Andersen, Hanne

AU - Baric, Ralph S.

AU - Carroll, Miles W.

AU - Cavaleri, Marco

AU - Qin, Chuan

AU - Crozier, Ian

AU - Dallmeier, Kai

AU - de Waal, Leon

AU - de Wit, Emmie

AU - Delang, Leen

AU - Dohm, Erik

AU - Duprex, W. Paul

AU - Falzarano, Darryl

AU - Finch, Courtney L.

AU - Frieman, Matthew B.

AU - Graham, Barney S.

AU - Gralinski, Lisa E.

AU - Guilfoyle, Kate

AU - Haagmans, Bart L.

AU - Hamilton, Geraldine A.

AU - Hartman, Amy L.

AU - Herfst, Sander

AU - Kaptein, Suzanne J.F.

AU - Klimstra, William B.

AU - Knezevic, Ivana

AU - Krause, Philip R.

AU - Kuhn, Jens H.

AU - Le Grand, Roger

AU - Lewis, Mark G.

AU - Liu, Wen Chun

AU - Maisonnasse, Pauline

AU - McElroy, Anita K.

AU - Munster, Vincent

AU - Oreshkova, Nadia

AU - Rasmussen, Angela L.

AU - Rocha-Pereira, Joana

AU - Rockx, Barry

AU - Rodríguez, Estefanía

AU - Rogers, Thomas F.

AU - Salguero, Francisco J.

AU - Schotsaert, Michael

AU - Stittelaar, Koert J.

AU - Thibaut, Hendrik Jan

AU - Tseng, Chien Te

AU - Vergara-Alert, Júlia

AU - Beer, Martin

AU - Brasel, Trevor

AU - Chan, Jasper F.W.

AU - García-Sastre, Adolfo

AU - Neyts, Johan

AU - Perlman, Stanley

AU - Reed, Douglas S.

AU - Richt, Juergen A.

AU - Roy, Chad J.

AU - Segalés, Joaquim

AU - Vasan, Seshadri S.

AU - Henao-Restrepo, Ana María

AU - Barouch, Dan H.

PY - 2020/10/22

Y1 - 2020/10/22

N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.

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DO - 10.1038/s41586-020-2787-6

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VL - 586

SP - 509

EP - 515

JO - Nature

JF - Nature

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Animal models for COVID-19

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