Animal models for COVID-19

César Muñoz-Fontela, William E. Dowling, Simon G.P. Funnell, Pierre S. Gsell, A. Ximena Riveros-Balta, Randy A. Albrecht, Hanne Andersen, Ralph S. Baric, Miles W. Carroll, Marco Cavaleri, Chuan Qin, Ian Crozier, Kai Dallmeier, Leon de Waal, Emmie de Wit, Leen Delang, Erik Dohm, W. Paul Duprex, Darryl Falzarano, Courtney L. FinchMatthew B. Frieman, Barney S. Graham, Lisa E. Gralinski, Kate Guilfoyle, Bart L. Haagmans, Geraldine A. Hamilton, Amy L. Hartman, Sander Herfst, Suzanne J.F. Kaptein, William B. Klimstra, Ivana Knezevic, Philip R. Krause, Jens H. Kuhn, Roger Le Grand, Mark G. Lewis, Wen Chun Liu, Pauline Maisonnasse, Anita K. McElroy, Vincent Munster, Nadia Oreshkova, Angela L. Rasmussen, Joana Rocha-Pereira, Barry Rockx, Estefanía Rodríguez, Thomas F. Rogers, Francisco J. Salguero, Michael Schotsaert, Koert J. Stittelaar, Hendrik Jan Thibaut, Chien Te Tseng, Júlia Vergara-Alert, Martin Beer, Trevor Brasel, Jasper F.W. Chan, Adolfo García-Sastre, Johan Neyts, Stanley Perlman, Douglas S. Reed, Juergen A. Richt, Chad J. Roy, Joaquim Segalés, Seshadri S. Vasan, Ana María Henao-Restrepo, Dan H. Barouch

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.

Original languageEnglish (US)
Pages (from-to)509-515
Number of pages7
JournalNature
Volume586
Issue number7830
DOIs
StatePublished - Oct 22 2020

ASJC Scopus subject areas

  • General

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