Animal models for highly pathogenic emerging viruses

David Safronetz, Thomas Geisbert, Heinz Feldmann

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Exotic and emerging viral pathogens associated with high morbidity and mortality in humans are being identified annually with recent examples including Lujo virus in southern Africa, Severe Fever with Thrombocytopenia Syndrome virus in China and a SARS-like coronavirus in the Middle East. The sporadic nature of these infections hampers our understanding of these diseases and limits the opportunities to design appropriate medical countermeasures against them. Because of this, animal models are utilized to gain insight into the pathogenesis of disease with the overall goal of identifying potential targets for intervention and evaluating specific therapeutics and vaccines. For these reasons it is imperative that animal models of disease recapitulate the human condition as closely as possible in order to provide the best predictive data with respect to the potential efficacy in humans. In this article we review the current status of disease models for highly pathogenic and emerging viral pathogens.

Original languageEnglish (US)
Pages (from-to)205-209
Number of pages5
JournalCurrent Opinion in Virology
Volume3
Issue number2
DOIs
StatePublished - Apr 2013

Fingerprint

Animal Models
Lujo virus
Viruses
SARS Virus
Animal Disease Models
Southern Africa
Middle East
Thrombocytopenia
China
Fever
Vaccines
Morbidity
Mortality
Infection
Therapeutics

ASJC Scopus subject areas

  • Virology

Cite this

Animal models for highly pathogenic emerging viruses. / Safronetz, David; Geisbert, Thomas; Feldmann, Heinz.

In: Current Opinion in Virology, Vol. 3, No. 2, 04.2013, p. 205-209.

Research output: Contribution to journalArticle

Safronetz, David ; Geisbert, Thomas ; Feldmann, Heinz. / Animal models for highly pathogenic emerging viruses. In: Current Opinion in Virology. 2013 ; Vol. 3, No. 2. pp. 205-209.
@article{9bb3b594584849d796847c38b91dc0fc,
title = "Animal models for highly pathogenic emerging viruses",
abstract = "Exotic and emerging viral pathogens associated with high morbidity and mortality in humans are being identified annually with recent examples including Lujo virus in southern Africa, Severe Fever with Thrombocytopenia Syndrome virus in China and a SARS-like coronavirus in the Middle East. The sporadic nature of these infections hampers our understanding of these diseases and limits the opportunities to design appropriate medical countermeasures against them. Because of this, animal models are utilized to gain insight into the pathogenesis of disease with the overall goal of identifying potential targets for intervention and evaluating specific therapeutics and vaccines. For these reasons it is imperative that animal models of disease recapitulate the human condition as closely as possible in order to provide the best predictive data with respect to the potential efficacy in humans. In this article we review the current status of disease models for highly pathogenic and emerging viral pathogens.",
author = "David Safronetz and Thomas Geisbert and Heinz Feldmann",
year = "2013",
month = "4",
doi = "10.1016/j.coviro.2013.01.001",
language = "English (US)",
volume = "3",
pages = "205--209",
journal = "Current Opinion in Virology",
issn = "1879-6257",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - Animal models for highly pathogenic emerging viruses

AU - Safronetz, David

AU - Geisbert, Thomas

AU - Feldmann, Heinz

PY - 2013/4

Y1 - 2013/4

N2 - Exotic and emerging viral pathogens associated with high morbidity and mortality in humans are being identified annually with recent examples including Lujo virus in southern Africa, Severe Fever with Thrombocytopenia Syndrome virus in China and a SARS-like coronavirus in the Middle East. The sporadic nature of these infections hampers our understanding of these diseases and limits the opportunities to design appropriate medical countermeasures against them. Because of this, animal models are utilized to gain insight into the pathogenesis of disease with the overall goal of identifying potential targets for intervention and evaluating specific therapeutics and vaccines. For these reasons it is imperative that animal models of disease recapitulate the human condition as closely as possible in order to provide the best predictive data with respect to the potential efficacy in humans. In this article we review the current status of disease models for highly pathogenic and emerging viral pathogens.

AB - Exotic and emerging viral pathogens associated with high morbidity and mortality in humans are being identified annually with recent examples including Lujo virus in southern Africa, Severe Fever with Thrombocytopenia Syndrome virus in China and a SARS-like coronavirus in the Middle East. The sporadic nature of these infections hampers our understanding of these diseases and limits the opportunities to design appropriate medical countermeasures against them. Because of this, animal models are utilized to gain insight into the pathogenesis of disease with the overall goal of identifying potential targets for intervention and evaluating specific therapeutics and vaccines. For these reasons it is imperative that animal models of disease recapitulate the human condition as closely as possible in order to provide the best predictive data with respect to the potential efficacy in humans. In this article we review the current status of disease models for highly pathogenic and emerging viral pathogens.

UR - http://www.scopus.com/inward/record.url?scp=84880074577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880074577&partnerID=8YFLogxK

U2 - 10.1016/j.coviro.2013.01.001

DO - 10.1016/j.coviro.2013.01.001

M3 - Article

VL - 3

SP - 205

EP - 209

JO - Current Opinion in Virology

JF - Current Opinion in Virology

SN - 1879-6257

IS - 2

ER -