Animal models for viral hemorrhagic fevers

Kelly L. Warfield, Thomas Geisbert

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Historically, the term viral hemorrhagic fever (VHF) refers to a clinical illness or syndrome characterized by high fever and a bleeding diathesis caused by a virus in one of four virus families [1]. The four virus families that cause VHF are Arenaviridae, Bunyaviridae, Flaviviridae, and Filoviridae. Currently, 12 specific viruses cause VHF, but the number is likely to expand as new viruses emerge. While all of the VHFs are caused by small RNA viruses with lipid envelopes [1], the viruses are biologically, geographically, and ecologically diverse. Most of the VHFs are zoonoses (transmissible from animal to man). The ecology and host reservoir of the viruses that cause VHF, except for the Filoviridae, are well-defined. Transmission to humans may occur from contact with the infected reservoir, a bite from an infected arthropod, aerosols generated from infected rodent excreta, or direct contact with infected patients or animal carcasses [2]. With the exception of the flaviviruses and Rift Valley fever (RVF), which are not considered transmissible from person to person, infected humans can spread VHF infection to close contacts [1,2].

Original languageEnglish (US)
Title of host publicationBiodefense Research Methodology and Animal Models, Second Edition
PublisherCRC Press
Pages271-310
Number of pages40
ISBN (Electronic)9781439836330
ISBN (Print)9781439836323
DOIs
StatePublished - Jan 1 2012

Fingerprint

Viral Hemorrhagic Fevers
fever
Animal Models
animal models
Viruses
viruses
Filoviridae
Flaviviridae
Arenaviridae
Rift Valley Fever
Bunyaviridae
Rift Valley fever
Flavivirus
disease reservoirs
Arthropods
RNA Viruses
Disease Susceptibility
Zoonoses
Bites and Stings
excreta

ASJC Scopus subject areas

  • veterinary(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Warfield, K. L., & Geisbert, T. (2012). Animal models for viral hemorrhagic fevers. In Biodefense Research Methodology and Animal Models, Second Edition (pp. 271-310). CRC Press. https://doi.org/10.1201/b11523

Animal models for viral hemorrhagic fevers. / Warfield, Kelly L.; Geisbert, Thomas.

Biodefense Research Methodology and Animal Models, Second Edition. CRC Press, 2012. p. 271-310.

Research output: Chapter in Book/Report/Conference proceedingChapter

Warfield, KL & Geisbert, T 2012, Animal models for viral hemorrhagic fevers. in Biodefense Research Methodology and Animal Models, Second Edition. CRC Press, pp. 271-310. https://doi.org/10.1201/b11523
Warfield KL, Geisbert T. Animal models for viral hemorrhagic fevers. In Biodefense Research Methodology and Animal Models, Second Edition. CRC Press. 2012. p. 271-310 https://doi.org/10.1201/b11523
Warfield, Kelly L. ; Geisbert, Thomas. / Animal models for viral hemorrhagic fevers. Biodefense Research Methodology and Animal Models, Second Edition. CRC Press, 2012. pp. 271-310
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