Anitschkow nuclear changes in postmortem pericardial scrapings

C. P. Molina, V. J. Schnadig

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To document the presence of Anitschkow nuclear changes (ANC) in pericardial mesothelium at autopsy after the incidental finding of ANC in pericardial scrapings from a fatal case of overwhelming sepsis. STUDY DESIGN: Fourteen, nonconsecutive autopsy cases were studied. Using the edge of a scalpel, the visceral pericardium from the left ventricle was scraped, and the sample was smeared onto glass slides, fixed in 95% ethanol, Papanicolaou stained and evaluated for the presence of ANC. Histologic correlation was also performed. RESULTS: ANC were observed in pericardial mesothelial cells in 6 of 14 cases. Sepsis was the cause of death in three. Fatal cardiac arrhythmia, T-cell lymphoma and fulminant hepatic necrosis were found in the remaining cases. While readily seen in cytologic preparations, ANC were found focally in only one case examined histologically. CONCLUSION: Postmortem cytologic evaluation provides information relevant to the autopsy. In this study, ANC were very clearly seen in six pericardial scrapings. Clinical correlation supports the current theory that ANC represent a nonspecific reactive cell change.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
JournalActa Cytologica
Volume45
Issue number2
StatePublished - 2001

Fingerprint

Postmortem Changes
Autopsy
Sepsis
Incidental Findings
T-Cell Lymphoma
Pericardium
Heart Ventricles
Glass
Cardiac Arrhythmias
Cause of Death
Ethanol
Necrosis
Epithelium
Liver

Keywords

  • Anitschkow nuclear changes
  • Autopsy
  • Pericardium

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

Cite this

Molina, C. P., & Schnadig, V. J. (2001). Anitschkow nuclear changes in postmortem pericardial scrapings. Acta Cytologica, 45(2), 197-200.

Anitschkow nuclear changes in postmortem pericardial scrapings. / Molina, C. P.; Schnadig, V. J.

In: Acta Cytologica, Vol. 45, No. 2, 2001, p. 197-200.

Research output: Contribution to journalArticle

Molina, CP & Schnadig, VJ 2001, 'Anitschkow nuclear changes in postmortem pericardial scrapings', Acta Cytologica, vol. 45, no. 2, pp. 197-200.
Molina, C. P. ; Schnadig, V. J. / Anitschkow nuclear changes in postmortem pericardial scrapings. In: Acta Cytologica. 2001 ; Vol. 45, No. 2. pp. 197-200.
@article{d37d77379f9e4d9cacda1d48baf6cd9b,
title = "Anitschkow nuclear changes in postmortem pericardial scrapings",
abstract = "OBJECTIVE: To document the presence of Anitschkow nuclear changes (ANC) in pericardial mesothelium at autopsy after the incidental finding of ANC in pericardial scrapings from a fatal case of overwhelming sepsis. STUDY DESIGN: Fourteen, nonconsecutive autopsy cases were studied. Using the edge of a scalpel, the visceral pericardium from the left ventricle was scraped, and the sample was smeared onto glass slides, fixed in 95{\%} ethanol, Papanicolaou stained and evaluated for the presence of ANC. Histologic correlation was also performed. RESULTS: ANC were observed in pericardial mesothelial cells in 6 of 14 cases. Sepsis was the cause of death in three. Fatal cardiac arrhythmia, T-cell lymphoma and fulminant hepatic necrosis were found in the remaining cases. While readily seen in cytologic preparations, ANC were found focally in only one case examined histologically. CONCLUSION: Postmortem cytologic evaluation provides information relevant to the autopsy. In this study, ANC were very clearly seen in six pericardial scrapings. Clinical correlation supports the current theory that ANC represent a nonspecific reactive cell change.",
keywords = "Anitschkow nuclear changes, Autopsy, Pericardium",
author = "Molina, {C. P.} and Schnadig, {V. J.}",
year = "2001",
language = "English (US)",
volume = "45",
pages = "197--200",
journal = "Acta Cytologica",
issn = "0001-5547",
publisher = "Science Printers and Publishers Inc.",
number = "2",

}

TY - JOUR

T1 - Anitschkow nuclear changes in postmortem pericardial scrapings

AU - Molina, C. P.

AU - Schnadig, V. J.

PY - 2001

Y1 - 2001

N2 - OBJECTIVE: To document the presence of Anitschkow nuclear changes (ANC) in pericardial mesothelium at autopsy after the incidental finding of ANC in pericardial scrapings from a fatal case of overwhelming sepsis. STUDY DESIGN: Fourteen, nonconsecutive autopsy cases were studied. Using the edge of a scalpel, the visceral pericardium from the left ventricle was scraped, and the sample was smeared onto glass slides, fixed in 95% ethanol, Papanicolaou stained and evaluated for the presence of ANC. Histologic correlation was also performed. RESULTS: ANC were observed in pericardial mesothelial cells in 6 of 14 cases. Sepsis was the cause of death in three. Fatal cardiac arrhythmia, T-cell lymphoma and fulminant hepatic necrosis were found in the remaining cases. While readily seen in cytologic preparations, ANC were found focally in only one case examined histologically. CONCLUSION: Postmortem cytologic evaluation provides information relevant to the autopsy. In this study, ANC were very clearly seen in six pericardial scrapings. Clinical correlation supports the current theory that ANC represent a nonspecific reactive cell change.

AB - OBJECTIVE: To document the presence of Anitschkow nuclear changes (ANC) in pericardial mesothelium at autopsy after the incidental finding of ANC in pericardial scrapings from a fatal case of overwhelming sepsis. STUDY DESIGN: Fourteen, nonconsecutive autopsy cases were studied. Using the edge of a scalpel, the visceral pericardium from the left ventricle was scraped, and the sample was smeared onto glass slides, fixed in 95% ethanol, Papanicolaou stained and evaluated for the presence of ANC. Histologic correlation was also performed. RESULTS: ANC were observed in pericardial mesothelial cells in 6 of 14 cases. Sepsis was the cause of death in three. Fatal cardiac arrhythmia, T-cell lymphoma and fulminant hepatic necrosis were found in the remaining cases. While readily seen in cytologic preparations, ANC were found focally in only one case examined histologically. CONCLUSION: Postmortem cytologic evaluation provides information relevant to the autopsy. In this study, ANC were very clearly seen in six pericardial scrapings. Clinical correlation supports the current theory that ANC represent a nonspecific reactive cell change.

KW - Anitschkow nuclear changes

KW - Autopsy

KW - Pericardium

UR - http://www.scopus.com/inward/record.url?scp=0035085953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035085953&partnerID=8YFLogxK

M3 - Article

C2 - 11284306

AN - SCOPUS:0035085953

VL - 45

SP - 197

EP - 200

JO - Acta Cytologica

JF - Acta Cytologica

SN - 0001-5547

IS - 2

ER -