Anomalous diffusion of DNA on a supported cationic lipid membrane

Chen Ming Chang, Yuk Gyn Lau, Shu Ching Ou, Tse Yu Lin, Wen Tau Juan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We used fluorescence microscopy to investigate the diffusion dynamics of individualDNA molecules on supported cationic lipid membranes. The mean-squared displacement of DNAon the membrane surface showed sub-diffusion associated with a slower DNA conformationalrelaxation at a short time scale. The evolution of contours of these non-entangled DNA at thisshort time scale was retained within a hypothetical tube of diameter 1 μ inhomogeneousDNA-surface interaction along the DNA contour, identified by total internal reflection fluorescencemicroscopy, suggested a mechanism for the anomalous dynamics of DNA on the membrane.

Original languageEnglish (US)
Article number38002
JournalEPL
Volume109
Issue number3
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

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lipids
deoxyribonucleic acid
membranes
surface reactions
tubes
microscopy
fluorescence
molecules

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Chang, C. M., Lau, Y. G., Ou, S. C., Lin, T. Y., & Juan, W. T. (2015). Anomalous diffusion of DNA on a supported cationic lipid membrane. EPL, 109(3), [38002]. https://doi.org/10.1209/0295-5075/109/38002

Anomalous diffusion of DNA on a supported cationic lipid membrane. / Chang, Chen Ming; Lau, Yuk Gyn; Ou, Shu Ching; Lin, Tse Yu; Juan, Wen Tau.

In: EPL, Vol. 109, No. 3, 38002, 01.02.2015.

Research output: Contribution to journalArticle

Chang, CM, Lau, YG, Ou, SC, Lin, TY & Juan, WT 2015, 'Anomalous diffusion of DNA on a supported cationic lipid membrane', EPL, vol. 109, no. 3, 38002. https://doi.org/10.1209/0295-5075/109/38002
Chang, Chen Ming ; Lau, Yuk Gyn ; Ou, Shu Ching ; Lin, Tse Yu ; Juan, Wen Tau. / Anomalous diffusion of DNA on a supported cationic lipid membrane. In: EPL. 2015 ; Vol. 109, No. 3.
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