Anomalous diffusion of DNA on a supported cationic lipid membrane

Chen Ming Chang, Yuk Gyn Lau, Shu Ching Ou, Tse Yu Lin, Wen Tau Juan

Research output: Contribution to journalArticle

3 Scopus citations


We used fluorescence microscopy to investigate the diffusion dynamics of individualDNA molecules on supported cationic lipid membranes. The mean-squared displacement of DNAon the membrane surface showed sub-diffusion associated with a slower DNA conformationalrelaxation at a short time scale. The evolution of contours of these non-entangled DNA at thisshort time scale was retained within a hypothetical tube of diameter 1 μ inhomogeneousDNA-surface interaction along the DNA contour, identified by total internal reflection fluorescencemicroscopy, suggested a mechanism for the anomalous dynamics of DNA on the membrane.

Original languageEnglish (US)
Article number38002
Issue number3
StatePublished - Feb 1 2015


ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Chang, C. M., Lau, Y. G., Ou, S. C., Lin, T. Y., & Juan, W. T. (2015). Anomalous diffusion of DNA on a supported cationic lipid membrane. EPL, 109(3), [38002].