Anomalous diffusion of DNA on a supported cationic lipid membrane

Chen Ming Chang; Yuk Gyn Lau; Shu Ching Ou; Tse Yu Lin; Wen Tau Juan

doi:10.1209/0295-5075/109/38002

Anomalous diffusion of DNA on a supported cationic lipid membrane

Chen Ming Chang
, Yuk Gyn Lau
, Shu Ching Ou
, Tse Yu Lin
, Wen Tau Juan

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We used fluorescence microscopy to investigate the diffusion dynamics of individualDNA molecules on supported cationic lipid membranes. The mean-squared displacement of DNAon the membrane surface showed sub-diffusion associated with a slower DNA conformationalrelaxation at a short time scale. The evolution of contours of these non-entangled DNA at thisshort time scale was retained within a hypothetical tube of diameter 1 μ inhomogeneousDNA-surface interaction along the DNA contour, identified by total internal reflection fluorescencemicroscopy, suggested a mechanism for the anomalous dynamics of DNA on the membrane.

Original language	English (US)
Article number	38002
Journal	EPL
Volume	109
Issue number	3
DOIs	https://doi.org/10.1209/0295-5075/109/38002
State	Published - Feb 1 2015
Externally published	Yes

ASJC Scopus subject areas

General Physics and Astronomy

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10.1209/0295-5075/109/38002

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title = "Anomalous diffusion of DNA on a supported cationic lipid membrane",

abstract = "We used fluorescence microscopy to investigate the diffusion dynamics of individualDNA molecules on supported cationic lipid membranes. The mean-squared displacement of DNAon the membrane surface showed sub-diffusion associated with a slower DNA conformationalrelaxation at a short time scale. The evolution of contours of these non-entangled DNA at thisshort time scale was retained within a hypothetical tube of diameter 1 μ inhomogeneousDNA-surface interaction along the DNA contour, identified by total internal reflection fluorescencemicroscopy, suggested a mechanism for the anomalous dynamics of DNA on the membrane.",

author = "Chang, \{Chen Ming\} and Lau, \{Yuk Gyn\} and Ou, \{Shu Ching\} and Lin, \{Tse Yu\} and Juan, \{Wen Tau\}",

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AU - Chang, Chen Ming

AU - Lau, Yuk Gyn

AU - Ou, Shu Ching

AU - Lin, Tse Yu

AU - Juan, Wen Tau

PY - 2015/2/1

Y1 - 2015/2/1

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AB - We used fluorescence microscopy to investigate the diffusion dynamics of individualDNA molecules on supported cationic lipid membranes. The mean-squared displacement of DNAon the membrane surface showed sub-diffusion associated with a slower DNA conformationalrelaxation at a short time scale. The evolution of contours of these non-entangled DNA at thisshort time scale was retained within a hypothetical tube of diameter 1 μ inhomogeneousDNA-surface interaction along the DNA contour, identified by total internal reflection fluorescencemicroscopy, suggested a mechanism for the anomalous dynamics of DNA on the membrane.

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Anomalous diffusion of DNA on a supported cationic lipid membrane

Abstract

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