Antagonism of the lsd cue by putative serotonin antagonists. Relationship to inhibition of in vivo [3H]spiroperidol binding

Erik B. Nielsen, Sheryl R. Ginn, Kathryn A. Cunningham, James B. Appel

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

In two groups of rats trained to discriminate 0.08 or 0.16 mg/kg of lysergic acid diethylamide (LSD) from saline, pirenperone and ketanserin completely blocked the stimulus effect of LSD. Pizotifen (BC-105) blocked the LSD cue when the training dose was 0.08 mg/kg, but had variable effects in the 0.16 mg/kg of LSD-trained group. The antagonism of the 0.08 mg/kg cue occurred at doses of the antagonists which blocked [3H]spiroperidol labeled 5-HT2 receptors in the frontal cortex in vivo; binding in the striatum was unaffected by the LSD antagonists. However, in doses which produce the LSD cue, neither LSD nor the 5-HT agonist, 5-methoxy-N,N-dimethyltryptamine, which substitutes for LSD, inhibited the binding in either the cortex or the striatum. The results are discussed in relation to the possible neuropharmacological basis for the LSD cue.

Original languageEnglish (US)
Pages (from-to)171-176
Number of pages6
JournalBehavioural Brain Research
Volume16
Issue number2-3
DOIs
StatePublished - Aug 1985
Externally publishedYes

Keywords

  • 5-hydroxytryptamine agonists
  • 5-hydroxytryptamine antagonists
  • [H]spiroperidol binding in vivo
  • drug discrimination
  • lysergic acid diethylamide
  • rat

ASJC Scopus subject areas

  • Behavioral Neuroscience

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