Abstract
The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), warranting urgent study of the molecular mechanisms of SARS-CoV-2 infection and host immune response. Type I interferon (IFN-I) is a key component of host innate immune system responsible for eliminating the virus at the early stage of infection. In contrast, SARS-CoV-2 has evolved multiple strategies to evade innate immune response to facilitate viral replication, transmission, and pathogenesis. This review summarizes the recent progresses on SARS-CoV-2 proteins that antagonize host IFN-I production and/or signaling. These progresses have provided knowledge for new vaccine and antiviral development to prevent and control COVID-19.
Original language | English (US) |
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Pages (from-to) | 543-548 |
Number of pages | 6 |
Journal | Journal of Interferon and Cytokine Research |
Volume | 40 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2020 |
Keywords
- COVID-19
- SARS-CoV-2
- immune evasion
- interferon
ASJC Scopus subject areas
- Immunology
- Cell Biology
- Virology
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Press / Media
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COVID-19 virus helps block host immunity
1/20/21 → 1/21/21
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