Antagonism of Type i Interferon by Severe Acute Respiratory Syndrome Coronavirus 2

Hongjie Xia, Pei Yong Shi

Research output: Contribution to journalReview articlepeer-review

Abstract

The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), warranting urgent study of the molecular mechanisms of SARS-CoV-2 infection and host immune response. Type I interferon (IFN-I) is a key component of host innate immune system responsible for eliminating the virus at the early stage of infection. In contrast, SARS-CoV-2 has evolved multiple strategies to evade innate immune response to facilitate viral replication, transmission, and pathogenesis. This review summarizes the recent progresses on SARS-CoV-2 proteins that antagonize host IFN-I production and/or signaling. These progresses have provided knowledge for new vaccine and antiviral development to prevent and control COVID-19.

Original languageEnglish (US)
Pages (from-to)543-548
Number of pages6
JournalJournal of Interferon and Cytokine Research
Volume40
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • COVID-19
  • SARS-CoV-2
  • immune evasion
  • interferon

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology

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