Abstract
Cerebral palsy is a leading cause of childhood neuromotor disability and is strongly associated with preterm delivery. Basic science research and some observational studies have suggested a neuroprotective benefit from antenatal exposure to magnesium sulfate. Recent randomized controlled studies and meta-analyses suggest that antenatal exposure to magnesium sulfate before anticipated preterm birth is associated with reduction in the risk of developing cerebral palsy or its associated neurologic disabilities in surviving infants. More importantly. this benefit has been achieved without increasing the risk of perinatal mortality.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 351-366 |
| Number of pages | 16 |
| Journal | Obstetrics and Gynecology Clinics of North America |
| Volume | 38 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 2011 |
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Keywords
- Cerebral palsy
- Magnesium sulfate
- Neuroprotection
- Pregnancy
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Antenatal Exposure to Magnesium Sulfate and Neuroprotection in Preterm Infants. / Costantine, Maged; Drever, Nathan.
In: Obstetrics and Gynecology Clinics of North America, Vol. 38, No. 2, 06.2011, p. 351-366.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antenatal Exposure to Magnesium Sulfate and Neuroprotection in Preterm Infants
AU - Costantine, Maged
AU - Drever, Nathan
PY - 2011/6
Y1 - 2011/6
N2 - Cerebral palsy is a leading cause of childhood neuromotor disability and is strongly associated with preterm delivery. Basic science research and some observational studies have suggested a neuroprotective benefit from antenatal exposure to magnesium sulfate. Recent randomized controlled studies and meta-analyses suggest that antenatal exposure to magnesium sulfate before anticipated preterm birth is associated with reduction in the risk of developing cerebral palsy or its associated neurologic disabilities in surviving infants. More importantly. this benefit has been achieved without increasing the risk of perinatal mortality.
AB - Cerebral palsy is a leading cause of childhood neuromotor disability and is strongly associated with preterm delivery. Basic science research and some observational studies have suggested a neuroprotective benefit from antenatal exposure to magnesium sulfate. Recent randomized controlled studies and meta-analyses suggest that antenatal exposure to magnesium sulfate before anticipated preterm birth is associated with reduction in the risk of developing cerebral palsy or its associated neurologic disabilities in surviving infants. More importantly. this benefit has been achieved without increasing the risk of perinatal mortality.
KW - Cerebral palsy
KW - Magnesium sulfate
KW - Neuroprotection
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=79955967563&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955967563&partnerID=8YFLogxK
U2 - 10.1016/j.ogc.2011.02.019
DO - 10.1016/j.ogc.2011.02.019
M3 - Article
C2 - 21575805
AN - SCOPUS:79955967563
VL - 38
SP - 351
EP - 366
JO - Obstetrics and Gynecology Clinics of North America
JF - Obstetrics and Gynecology Clinics of North America
SN - 0889-8545
IS - 2
ER -