Antenatal Exposure to Magnesium Sulfate and Neuroprotection in Preterm Infants

Maged Costantine, Nathan Drever

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Cerebral palsy is a leading cause of childhood neuromotor disability and is strongly associated with preterm delivery. Basic science research and some observational studies have suggested a neuroprotective benefit from antenatal exposure to magnesium sulfate. Recent randomized controlled studies and meta-analyses suggest that antenatal exposure to magnesium sulfate before anticipated preterm birth is associated with reduction in the risk of developing cerebral palsy or its associated neurologic disabilities in surviving infants. More importantly. this benefit has been achieved without increasing the risk of perinatal mortality.

Original languageEnglish (US)
Pages (from-to)351-366
Number of pages16
JournalObstetrics and Gynecology Clinics of North America
Volume38
Issue number2
DOIs
StatePublished - Jun 2011

Fingerprint

Magnesium Sulfate
Cerebral Palsy
Premature Infants
Perinatal Mortality
Premature Birth
Risk Reduction Behavior
Nervous System
Observational Studies
Meta-Analysis
Research
Neuroprotection

Keywords

  • Cerebral palsy
  • Magnesium sulfate
  • Neuroprotection
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Antenatal Exposure to Magnesium Sulfate and Neuroprotection in Preterm Infants. / Costantine, Maged; Drever, Nathan.

In: Obstetrics and Gynecology Clinics of North America, Vol. 38, No. 2, 06.2011, p. 351-366.

Research output: Contribution to journalArticle

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