Antenatal Magnesium and Cerebral Palsy in Preterm Infants

Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    OBJECTIVE: To evaluate the relationship of maternal antenatal magnesium sulfate (MgSO4) with neonatal cranial ultrasound abnormalities and cerebral palsy (CP).

    STUDY DESIGN: In a randomized trial of MgSO4 or placebo in women at high risk of preterm delivery, up to 3 cranial ultrasounds were obtained in the neonatal period. Images were reviewed by at least 2 pediatric radiologists masked to treatment and other clinical conditions. Diagnoses were predefined for intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly. CP was diagnosed at 2 years of age by standardized neurologic examination.

    RESULTS: Intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly were all strongly associated with an increased risk of CP. MgSO4 administration did not affect the risk of cranial ultrasound abnormality observed at 35 weeks postmenstrual age or later. However, for the 82% of infants born at

    CONCLUSIONS: MgSO4 given prior to preterm delivery was associated with decreased risk of developing echodensities and echolucencies at

    TRIAL REGISTRATION: ClinicalTrials.gov: NCT00014989.

    Original languageEnglish (US)
    Pages (from-to)834-839
    Number of pages6
    JournalJournal of Pediatrics
    Volume167
    Issue number4
    DOIs
    StatePublished - Oct 1 2015

    Fingerprint

    Cerebral Palsy
    Premature Infants
    Magnesium
    Periventricular Leukomalacia
    Hemorrhage
    Magnesium Sulfate
    Neurologic Examination
    Placebos
    Mothers
    Pediatrics
    Therapeutics

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (2015). Antenatal Magnesium and Cerebral Palsy in Preterm Infants. Journal of Pediatrics, 167(4), 834-839. https://doi.org/10.1016/j.jpeds.2015.06.067

    Antenatal Magnesium and Cerebral Palsy in Preterm Infants. / Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.

    In: Journal of Pediatrics, Vol. 167, No. 4, 01.10.2015, p. 834-839.

    Research output: Contribution to journalArticle

    Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network 2015, 'Antenatal Magnesium and Cerebral Palsy in Preterm Infants', Journal of Pediatrics, vol. 167, no. 4, pp. 834-839. https://doi.org/10.1016/j.jpeds.2015.06.067
    Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Antenatal Magnesium and Cerebral Palsy in Preterm Infants. Journal of Pediatrics. 2015 Oct 1;167(4):834-839. https://doi.org/10.1016/j.jpeds.2015.06.067
    Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. / Antenatal Magnesium and Cerebral Palsy in Preterm Infants. In: Journal of Pediatrics. 2015 ; Vol. 167, No. 4. pp. 834-839.
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    author = "{Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network} and Hirtz, {Deborah G.} and Weiner, {Steven J.} and Dorothy Bulas and Michael DiPietro and Joanna Seibert and Rouse, {Dwight J.} and Mercer, {Brian M.} and Varner, {Michael W.} and Reddy, {Uma M.} and Iams, {Jay D.} and Wapner, {Ronald J.} and Yoram Sorokin and Thorp, {John M.} and Ramin, {Susan M.} and Malone, {Fergal D.} and Carpenter, {Marshall W.} and O'Sullivan, {Mary J.} and Peaceman, {Alan M.} and Gary Hankins and Donald Dudley and Dora Martin",
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    AU - Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network

    AU - Hirtz, Deborah G.

    AU - Weiner, Steven J.

    AU - Bulas, Dorothy

    AU - DiPietro, Michael

    AU - Seibert, Joanna

    AU - Rouse, Dwight J.

    AU - Mercer, Brian M.

    AU - Varner, Michael W.

    AU - Reddy, Uma M.

    AU - Iams, Jay D.

    AU - Wapner, Ronald J.

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    AU - Malone, Fergal D.

    AU - Carpenter, Marshall W.

    AU - O'Sullivan, Mary J.

    AU - Peaceman, Alan M.

    AU - Hankins, Gary

    AU - Dudley, Donald

    AU - Martin, Dora

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    N2 - OBJECTIVE: To evaluate the relationship of maternal antenatal magnesium sulfate (MgSO4) with neonatal cranial ultrasound abnormalities and cerebral palsy (CP).STUDY DESIGN: In a randomized trial of MgSO4 or placebo in women at high risk of preterm delivery, up to 3 cranial ultrasounds were obtained in the neonatal period. Images were reviewed by at least 2 pediatric radiologists masked to treatment and other clinical conditions. Diagnoses were predefined for intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly. CP was diagnosed at 2 years of age by standardized neurologic examination.RESULTS: Intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly were all strongly associated with an increased risk of CP. MgSO4 administration did not affect the risk of cranial ultrasound abnormality observed at 35 weeks postmenstrual age or later. However, for the 82% of infants born at CONCLUSIONS: MgSO4 given prior to preterm delivery was associated with decreased risk of developing echodensities and echolucencies at TRIAL REGISTRATION: ClinicalTrials.gov: NCT00014989.

    AB - OBJECTIVE: To evaluate the relationship of maternal antenatal magnesium sulfate (MgSO4) with neonatal cranial ultrasound abnormalities and cerebral palsy (CP).STUDY DESIGN: In a randomized trial of MgSO4 or placebo in women at high risk of preterm delivery, up to 3 cranial ultrasounds were obtained in the neonatal period. Images were reviewed by at least 2 pediatric radiologists masked to treatment and other clinical conditions. Diagnoses were predefined for intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly. CP was diagnosed at 2 years of age by standardized neurologic examination.RESULTS: Intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly were all strongly associated with an increased risk of CP. MgSO4 administration did not affect the risk of cranial ultrasound abnormality observed at 35 weeks postmenstrual age or later. However, for the 82% of infants born at CONCLUSIONS: MgSO4 given prior to preterm delivery was associated with decreased risk of developing echodensities and echolucencies at TRIAL REGISTRATION: ClinicalTrials.gov: NCT00014989.

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