Anti-CD4 antibodies are associated with HIV-1 seroconversion and may be detectable before Anti-HIV-1 antibodies

Philip Keiser, S. Keay, S. Wasserman, W. Wecksler, A. Saah, J. Palenicek, J. Margolick, J. McArthur, H. Fazadegan, H. Armenian, N. Graham, J. Phair, J. Chmiel, K. Sheridan, B. Cohen, S. Wolinsky, R. Detels, B. Vischer, J. Fahey

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Abstract

We examined the sera from 14 HIV-1 seroconverters for the presence of autoantibodies against CD4. Anti-CD4 antibodies were detected in the serum of 11 of 13 HIV-1-infected persons at the time of HIV-1 seroconversion. In 6 of 14 persons from whom a serum was obtained prior to HIV-1 seroconversion, anti-CD4 antibodies were found 90 to 540 days before antibodies to HIV-1 were detectable. In comparison, anti-CD4 antibodies were present in only 7 serum samples from 62 HIV-1 seronegative individuals, including 50 from a seronegative homosexual male cohort. These results suggest that anti-CD4 antibodies are generated in response to early HIV-1 infection and possibly could be used as a marker for HIV-1 infection in some infected persons who are seronegative for HIV-1.

Original languageEnglish (US)
Pages (from-to)1919-1927
Number of pages9
JournalAIDS Research and Human Retroviruses
Volume8
Issue number11
StatePublished - 1992
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Keiser, P., Keay, S., Wasserman, S., Wecksler, W., Saah, A., Palenicek, J., Margolick, J., McArthur, J., Fazadegan, H., Armenian, H., Graham, N., Phair, J., Chmiel, J., Sheridan, K., Cohen, B., Wolinsky, S., Detels, R., Vischer, B., & Fahey, J. (1992). Anti-CD4 antibodies are associated with HIV-1 seroconversion and may be detectable before Anti-HIV-1 antibodies. AIDS Research and Human Retroviruses, 8(11), 1919-1927.