Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus

Wei Zhang, Yan Cheng Xu, Fangjian Guo, Ye Meng, Ming Li Li

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background: Retinol binding protein 4 (RBP4), as an adipocyte secreted cytokine, was recently found to be inversely correlated with expression of glucose transporter 4 (GLUT4) in insulin resistance (IR) state and to have an intimate relationship with IR and type 2 diabetes mellitus (T2DM). The present study aimed to evaluate the anti-diabetic efficacy of cinnamaldehyde (Cin), berberine (Ber), and metformin (Met) as well as their impacts on the RBP4-GLUT4 system. Methods: Rat models of T2DM were established by combination of intraperitoneal injection of low-dose streptozotocin and high fat diet induction. Rats were divided into five groups: the control group, the diabetes group, the diabetes+Ber group, the diabetes+Cin group, and the diabetes+Met group. Western blotting was used to detect the serum or tissue RBP4 and GLUT4 protein levels. Results: After treatment for four weeks, both Cin and Ber displayed significant hypolipidemic, hypoglycemic, and insulin sensitizing functions (P

Original languageEnglish (US)
Pages (from-to)2124-2128
Number of pages5
JournalChinese Medical Journal
Volume121
Issue number21
StatePublished - Nov 5 2008
Externally publishedYes

Fingerprint

Berberine
Retinol-Binding Proteins
Facilitative Glucose Transport Proteins
Type 2 Diabetes Mellitus
Metformin
Insulin Resistance
High Fat Diet
Streptozocin
Intraperitoneal Injections
Hypoglycemic Agents
Adipocytes
Western Blotting
Insulin
Cytokines
Control Groups
Serum
cinnamic aldehyde
Proteins
Therapeutics

Keywords

  • Berberine
  • Cinnamaldehyde
  • Glucose transporter 4
  • Insulin resistance
  • Retinol binding protein 4
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus. / Zhang, Wei; Xu, Yan Cheng; Guo, Fangjian; Meng, Ye; Li, Ming Li.

In: Chinese Medical Journal, Vol. 121, No. 21, 05.11.2008, p. 2124-2128.

Research output: Contribution to journalArticle

@article{9df9d20636aa4cbaa9a4ac51c84d0f12,
title = "Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus",
abstract = "Background: Retinol binding protein 4 (RBP4), as an adipocyte secreted cytokine, was recently found to be inversely correlated with expression of glucose transporter 4 (GLUT4) in insulin resistance (IR) state and to have an intimate relationship with IR and type 2 diabetes mellitus (T2DM). The present study aimed to evaluate the anti-diabetic efficacy of cinnamaldehyde (Cin), berberine (Ber), and metformin (Met) as well as their impacts on the RBP4-GLUT4 system. Methods: Rat models of T2DM were established by combination of intraperitoneal injection of low-dose streptozotocin and high fat diet induction. Rats were divided into five groups: the control group, the diabetes group, the diabetes+Ber group, the diabetes+Cin group, and the diabetes+Met group. Western blotting was used to detect the serum or tissue RBP4 and GLUT4 protein levels. Results: After treatment for four weeks, both Cin and Ber displayed significant hypolipidemic, hypoglycemic, and insulin sensitizing functions (P",
keywords = "Berberine, Cinnamaldehyde, Glucose transporter 4, Insulin resistance, Retinol binding protein 4, Type 2 diabetes mellitus",
author = "Wei Zhang and Xu, {Yan Cheng} and Fangjian Guo and Ye Meng and Li, {Ming Li}",
year = "2008",
month = "11",
day = "5",
language = "English (US)",
volume = "121",
pages = "2124--2128",
journal = "Chinese Medical Journal",
issn = "0366-6999",
publisher = "Chinese Medical Association",
number = "21",

}

TY - JOUR

T1 - Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus

AU - Zhang, Wei

AU - Xu, Yan Cheng

AU - Guo, Fangjian

AU - Meng, Ye

AU - Li, Ming Li

PY - 2008/11/5

Y1 - 2008/11/5

N2 - Background: Retinol binding protein 4 (RBP4), as an adipocyte secreted cytokine, was recently found to be inversely correlated with expression of glucose transporter 4 (GLUT4) in insulin resistance (IR) state and to have an intimate relationship with IR and type 2 diabetes mellitus (T2DM). The present study aimed to evaluate the anti-diabetic efficacy of cinnamaldehyde (Cin), berberine (Ber), and metformin (Met) as well as their impacts on the RBP4-GLUT4 system. Methods: Rat models of T2DM were established by combination of intraperitoneal injection of low-dose streptozotocin and high fat diet induction. Rats were divided into five groups: the control group, the diabetes group, the diabetes+Ber group, the diabetes+Cin group, and the diabetes+Met group. Western blotting was used to detect the serum or tissue RBP4 and GLUT4 protein levels. Results: After treatment for four weeks, both Cin and Ber displayed significant hypolipidemic, hypoglycemic, and insulin sensitizing functions (P

AB - Background: Retinol binding protein 4 (RBP4), as an adipocyte secreted cytokine, was recently found to be inversely correlated with expression of glucose transporter 4 (GLUT4) in insulin resistance (IR) state and to have an intimate relationship with IR and type 2 diabetes mellitus (T2DM). The present study aimed to evaluate the anti-diabetic efficacy of cinnamaldehyde (Cin), berberine (Ber), and metformin (Met) as well as their impacts on the RBP4-GLUT4 system. Methods: Rat models of T2DM were established by combination of intraperitoneal injection of low-dose streptozotocin and high fat diet induction. Rats were divided into five groups: the control group, the diabetes group, the diabetes+Ber group, the diabetes+Cin group, and the diabetes+Met group. Western blotting was used to detect the serum or tissue RBP4 and GLUT4 protein levels. Results: After treatment for four weeks, both Cin and Ber displayed significant hypolipidemic, hypoglycemic, and insulin sensitizing functions (P

KW - Berberine

KW - Cinnamaldehyde

KW - Glucose transporter 4

KW - Insulin resistance

KW - Retinol binding protein 4

KW - Type 2 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=58149360797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149360797&partnerID=8YFLogxK

M3 - Article

VL - 121

SP - 2124

EP - 2128

JO - Chinese Medical Journal

JF - Chinese Medical Journal

SN - 0366-6999

IS - 21

ER -