Anti-inflammatory and cytoprotective effects of inosine

Csaba Szabo, Domokos Gerô, György Haskó

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Inosine can be formed intracellularly as well as extracellularly. The two major routes for the intracellular formation of inosine are the deamination of adenosine to inosine by intracellular adenosine deaminase and the dephosphorylation of inosine monophosphate to inosine by 5′-nucleotidase (Figure 15.1). This deamination of adenosine to inosine occurs mainly at high intracellular adenosine concentrations associated with hypoxia, ischemia, and other forms of cellular stress. 1 Once inosine reaches high concentrations inside the cell, it is shunted into the extracellular space via the operation of bidirectional equilibrative nucleoside transporters (Figure 15.1). 2 Consistent with the fact that inosine exerts its most powerful regulatory actions in the immune system (see the following text), adenosine deaminase expression is highest in lymphoid tissues. 3 The extracellular formation of inosine is the result of conversion of adenosine to inosine by extracellular (plasma or cell surface) adenosine deaminase. Similar to inosine, adenosine is liberated from cells during metabolic stress.

Original languageEnglish (US)
Title of host publicationAdenosine Receptors
Subtitle of host publicationTherapeutic Aspects for Inflammatory and Immune Diseases
PublisherCRC Press
Pages237-256
Number of pages20
ISBN (Electronic)9781420005776
ISBN (Print)0849339995, 9780849339998
StatePublished - Jan 1 2006
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Immunology and Microbiology(all)

Cite this

Szabo, C., Gerô, D., & Haskó, G. (2006). Anti-inflammatory and cytoprotective effects of inosine. In Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases (pp. 237-256). CRC Press.