Anti-inflammatory effect of dikaempferol rhamnopyranoside, a diflavonoid from Eugenia jambolana Lam. Leaves

M. C. Lingaraju, S. Anand, J. Begum, V. Balaganur, R. R. Kumari, R. A. Bhat, A. S. More, D. Kumar, B. K. Bhadoria, S. K. Tandan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Traditionally, the Indian Blackberry or locally called Jamun, Eugenia jambolana Lam. (Syn.: Syzygium cumini), is well known for its pharmacological potential, particularly anti-inflammatory. Here, we studied kaempferol-7-O-α-Lrhamnopyranoside]-4'-O-4'-[kaempferol-7-O-α-L-rhamnopyranoside (EJ-01) isolated from the E. jambolana leaves for possible anti-inflammatory activity. EJ-01 (3, 10 and 30 mg/kg, p.o.) was assessed for anti-inflammatory activity using carrageenan-induced paw edema model in mice by determining edema volume, myeloperoxidase (MPO), nitrite plus nitrate (NOx) and cytokine levels in paw edema tissue. EJ-01 significantly attenuated the edema, MPO levels, tumor necrosis factor-alpha (TNF-α) and interleukin-1beta (IL-1β) levels in the edema of paw at the 5th hour after carrageenan injection at all doses. EJ-01 (30 mg/kg) decreased the nitric oxide (NO) levels of the edema of paw at the 5th hour after carrageenan injection. The anti-inflammatory mechanisms of EJ-01 might be related to the decrease in the level of edema paw by reduced activities of NO and MPO. It probably exerts anti-inflammatory effects through the suppression of TNF-α and IL-1β. Therefore, we conclude that EJ-01 could be positively exploited for itspotential benefits against inflammatory diseases and support the pharmacological basis of E. jambolana as traditional herbal medicine for the treatment of inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)801-807
Number of pages7
JournalIndian Journal of Experimental Biology
Volume54
Issue number12
StatePublished - Dec 1 2016
Externally publishedYes

Fingerprint

Syzygium
Edema
Anti-Inflammatory Agents
Carrageenan
Peroxidase
Interleukin-1beta
Nitric Oxide
Tumor Necrosis Factor-alpha
Pharmacology
Injections
Herbal Medicine
Traditional Medicine
Nitrites
Nitrates
Cytokines

Keywords

  • Diflavonoid
  • Indian blackberry
  • Jamun
  • Java plum
  • Syzygium cumini

ASJC Scopus subject areas

  • Biotechnology
  • Medicine(all)
  • Molecular Biology
  • Cell Biology

Cite this

Lingaraju, M. C., Anand, S., Begum, J., Balaganur, V., Kumari, R. R., Bhat, R. A., ... Tandan, S. K. (2016). Anti-inflammatory effect of dikaempferol rhamnopyranoside, a diflavonoid from Eugenia jambolana Lam. Leaves. Indian Journal of Experimental Biology, 54(12), 801-807.

Anti-inflammatory effect of dikaempferol rhamnopyranoside, a diflavonoid from Eugenia jambolana Lam. Leaves. / Lingaraju, M. C.; Anand, S.; Begum, J.; Balaganur, V.; Kumari, R. R.; Bhat, R. A.; More, A. S.; Kumar, D.; Bhadoria, B. K.; Tandan, S. K.

In: Indian Journal of Experimental Biology, Vol. 54, No. 12, 01.12.2016, p. 801-807.

Research output: Contribution to journalArticle

Lingaraju, MC, Anand, S, Begum, J, Balaganur, V, Kumari, RR, Bhat, RA, More, AS, Kumar, D, Bhadoria, BK & Tandan, SK 2016, 'Anti-inflammatory effect of dikaempferol rhamnopyranoside, a diflavonoid from Eugenia jambolana Lam. Leaves', Indian Journal of Experimental Biology, vol. 54, no. 12, pp. 801-807.
Lingaraju MC, Anand S, Begum J, Balaganur V, Kumari RR, Bhat RA et al. Anti-inflammatory effect of dikaempferol rhamnopyranoside, a diflavonoid from Eugenia jambolana Lam. Leaves. Indian Journal of Experimental Biology. 2016 Dec 1;54(12):801-807.
Lingaraju, M. C. ; Anand, S. ; Begum, J. ; Balaganur, V. ; Kumari, R. R. ; Bhat, R. A. ; More, A. S. ; Kumar, D. ; Bhadoria, B. K. ; Tandan, S. K. / Anti-inflammatory effect of dikaempferol rhamnopyranoside, a diflavonoid from Eugenia jambolana Lam. Leaves. In: Indian Journal of Experimental Biology. 2016 ; Vol. 54, No. 12. pp. 801-807.
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abstract = "Traditionally, the Indian Blackberry or locally called Jamun, Eugenia jambolana Lam. (Syn.: Syzygium cumini), is well known for its pharmacological potential, particularly anti-inflammatory. Here, we studied kaempferol-7-O-α-Lrhamnopyranoside]-4'-O-4'-[kaempferol-7-O-α-L-rhamnopyranoside (EJ-01) isolated from the E. jambolana leaves for possible anti-inflammatory activity. EJ-01 (3, 10 and 30 mg/kg, p.o.) was assessed for anti-inflammatory activity using carrageenan-induced paw edema model in mice by determining edema volume, myeloperoxidase (MPO), nitrite plus nitrate (NOx) and cytokine levels in paw edema tissue. EJ-01 significantly attenuated the edema, MPO levels, tumor necrosis factor-alpha (TNF-α) and interleukin-1beta (IL-1β) levels in the edema of paw at the 5th hour after carrageenan injection at all doses. EJ-01 (30 mg/kg) decreased the nitric oxide (NO) levels of the edema of paw at the 5th hour after carrageenan injection. The anti-inflammatory mechanisms of EJ-01 might be related to the decrease in the level of edema paw by reduced activities of NO and MPO. It probably exerts anti-inflammatory effects through the suppression of TNF-α and IL-1β. Therefore, we conclude that EJ-01 could be positively exploited for itspotential benefits against inflammatory diseases and support the pharmacological basis of E. jambolana as traditional herbal medicine for the treatment of inflammatory diseases.",
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AU - Begum, J.

AU - Balaganur, V.

AU - Kumari, R. R.

AU - Bhat, R. A.

AU - More, A. S.

AU - Kumar, D.

AU - Bhadoria, B. K.

AU - Tandan, S. K.

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