TY - JOUR
T1 - Anti-Proliferative Naphthalene Glucoside from Aerial Part of Neanotis wightiana
AU - Das, Niranjan
AU - Deb, Prashanta Kumar
AU - Ali, Eunus S.
AU - Das, Manash C.
AU - Sarkar, Biswatrish
AU - Mishra, Siddhartha Kumar
N1 - Publisher Copyright:
© 2022, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/1
Y1 - 2022/1
N2 - A new bioactive naphthalene glucoside, named neanoside C (1), was isolated from the aerial part of Neanotis wightiana. The structure of neanoside C (1) was elucidated as 1,4-dihydroxy-2-(6′-Omethylglucopyranosyloxymethyl)-naphthalene-3-vinyloxyglucopyranoside by interpretation of the spectroscopic data, including 2D NMR and chemical studies. Neanoside C (1) was further subjected to screening for anticancer potential using MTT based cytotoxicity assay, LDH leakage assay, and estimation of intracellular ROS production in two human breast cancer cell line. The compound exhibited promising anti-proliferative and cytotoxic effect against MCF-7 and MDA-MB-231 cell lines with an IC50 value of 22.77 nM and 35.71 nM, respectively. Neanoside C (1) also exhibited concentration-dependent intracellular LDH leakage and ROS production.
AB - A new bioactive naphthalene glucoside, named neanoside C (1), was isolated from the aerial part of Neanotis wightiana. The structure of neanoside C (1) was elucidated as 1,4-dihydroxy-2-(6′-Omethylglucopyranosyloxymethyl)-naphthalene-3-vinyloxyglucopyranoside by interpretation of the spectroscopic data, including 2D NMR and chemical studies. Neanoside C (1) was further subjected to screening for anticancer potential using MTT based cytotoxicity assay, LDH leakage assay, and estimation of intracellular ROS production in two human breast cancer cell line. The compound exhibited promising anti-proliferative and cytotoxic effect against MCF-7 and MDA-MB-231 cell lines with an IC50 value of 22.77 nM and 35.71 nM, respectively. Neanoside C (1) also exhibited concentration-dependent intracellular LDH leakage and ROS production.
KW - anti-proliferative
KW - cytotoxic
KW - naphthalene glucoside
KW - Neanotis wightiana
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U2 - 10.1007/s10600-022-03591-3
DO - 10.1007/s10600-022-03591-3
M3 - Article
AN - SCOPUS:85125091456
SN - 0009-3130
VL - 58
SP - 21
EP - 26
JO - Chemistry of Natural Compounds
JF - Chemistry of Natural Compounds
IS - 1
ER -