Antiangiogenic agent as a novel treatment for pediatric intracranial arteriovenous malformations: Case report

Ken Maynard, Melissa LoPresti, Ionela Iacobas, Peter Kan, Sandi Lam

Research output: Contribution to journalArticle

Abstract

Intracerebral arteriovenous malformations (AVMs) are high-flow collections of abnormal vessels and a common cause of pediatric intracranial hemorrhage. There are few treatment options available for AVMs not amenable to surgical resection, endovascular embolization, radiosurgery, or multimodality treatment. The authors sought to review the molecular and genetic pathways that have been implicated in the formation of AVMs, focusing on the possibility of medically targeting these pathways in the treatment of AVMs. In the novel case presented here, a pediatric patient who was diagnosed with an intracranial AVM unamenable to conventional treatments underwent alternative treatment with molecular pathway inhibitors.

Original languageEnglish (US)
Pages (from-to)673-679
Number of pages7
JournalJournal of Neurosurgery: Pediatrics
Volume24
Issue number6
DOIs
StatePublished - 2019
Externally publishedYes

Keywords

  • Angiogenesis
  • Arteriovenous malformations
  • Pediatric
  • Vascular disorders
  • Vascular genetics

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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