Antibacterial activity of ciprofloxacin and trimethoprim, alone and in combination, against Vibrio cholerae O1 biotype El Tor serotype Ogawa isolates

Shyamapada Mandal, Nishith K. Pal, Imran H. Chowdhury, Manisha Debmandal

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

In this communication, the ciprofloxacin-trimethoprim (Cp-Tm) combination showed synergistic (Fractional Inhibitory Concentration, FIC index 0.399) and additive (FIC index 0.665-0.83) effects against Vibrio cholerae O1 biotype El Tor serotype Ogawa isolates having Cp MICs 10 μg/ml and Cp 0.66 μg/ml, respectively, following agar dilution checkerboard method. The time-kill study results demonstrated synergy between Cp and Tm against both groups of isolates providing 2.04 log10 (for strain with Cp MIC 0.66 μg/ml) and 3.12 log10 (for strain with Cp MIC 10 μg/ml) decreases in CFU/ml between the combination and its most active compound. Thus, the findings of the present study suggest an introduction of Cp-Tm combination treatment regimen against drug resistant cholera and this in turn will help in combating the drug resistance of V. cholerae O1 biotype El Tor serotype Ogawa.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalPolish Journal of Microbiology
Volume58
Issue number1
StatePublished - 2009
Externally publishedYes

Keywords

  • Antibacterial activity
  • Ciprofloxacin
  • Fractional inhibitory concentration index
  • Trimethoprim

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology
  • Microbiology (medical)

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