Abstract
In this communication, the ciprofloxacin-trimethoprim (Cp-Tm) combination showed synergistic (Fractional Inhibitory Concentration, FIC index 0.399) and additive (FIC index 0.665-0.83) effects against Vibrio cholerae O1 biotype El Tor serotype Ogawa isolates having Cp MICs 10 μg/ml and Cp 0.66 μg/ml, respectively, following agar dilution checkerboard method. The time-kill study results demonstrated synergy between Cp and Tm against both groups of isolates providing 2.04 log10 (for strain with Cp MIC 0.66 μg/ml) and 3.12 log10 (for strain with Cp MIC 10 μg/ml) decreases in CFU/ml between the combination and its most active compound. Thus, the findings of the present study suggest an introduction of Cp-Tm combination treatment regimen against drug resistant cholera and this in turn will help in combating the drug resistance of V. cholerae O1 biotype El Tor serotype Ogawa.
Original language | English (US) |
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Pages (from-to) | 57-60 |
Number of pages | 4 |
Journal | Polish Journal of Microbiology |
Volume | 58 |
Issue number | 1 |
State | Published - 2009 |
Externally published | Yes |
Keywords
- Antibacterial activity
- Ciprofloxacin
- Fractional inhibitory concentration index
- Trimethoprim
ASJC Scopus subject areas
- Microbiology
- Applied Microbiology and Biotechnology
- Microbiology (medical)