Antibodies to hemorrhagic fever viruses in domestic livestock in Niger

Rift Valley fever and Crimean-Congo hemorrhagic fever

J. C. Mariner, J. Morrill, Thomas Ksiazek

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A repository of domestic animal sera collected in Niger between 1984 and 1988 was assayed for antibody against two zoonotic hemorrhagic fever viruses known to be present in the West African Sahel. A total of 2,540 serum samples from 2,324 cattle, sheep, goats, and camels were tested by an IgG-specific enzyme-linked immunosorbent assay (ELISA) and the 80% plaque reduction neutralization test (PRNT80) for Rift Valley fever (RVF) virus antibody. Of the 2,540 sera tested for RVF-specific IgG antibody, 1,676 sera from cattle, sheep, and goats were examined for RVF-specific IgM antibody by ELISA. A subset of 2,263 sera were examined for evidence of Crimean-Congo hemorrhagic fever (CCHF) virus antibody by an IgG-specific ELISA. Antibody against CCHF virus was found to be most prevalent in adult cattle (422 of 732 or 57.7% positive) sampled at nine locations in the Niamey area. The highest prevalence for RVF neutralizing antibodies was found in camels from the Agadez Department with 67 (47.5%) of 141 positive. The results indicate that both CCHF and RVF viruses are circulating in Niger and are potential zoonotic health risks.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume53
Issue number3
StatePublished - 1995
Externally publishedYes

Fingerprint

Crimean Hemorrhagic Fever
Rift Valley Fever
Congo
Niger
Livestock
Fever
Viruses
Antibodies
Crimean-Congo hemorrhagic fever virus
Rift Valley fever virus
Camelus
Serum
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Zoonoses
Goats
Sheep
Neutralization Tests
Domestic Animals
Neutralizing Antibodies

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

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title = "Antibodies to hemorrhagic fever viruses in domestic livestock in Niger: Rift Valley fever and Crimean-Congo hemorrhagic fever",
abstract = "A repository of domestic animal sera collected in Niger between 1984 and 1988 was assayed for antibody against two zoonotic hemorrhagic fever viruses known to be present in the West African Sahel. A total of 2,540 serum samples from 2,324 cattle, sheep, goats, and camels were tested by an IgG-specific enzyme-linked immunosorbent assay (ELISA) and the 80{\%} plaque reduction neutralization test (PRNT80) for Rift Valley fever (RVF) virus antibody. Of the 2,540 sera tested for RVF-specific IgG antibody, 1,676 sera from cattle, sheep, and goats were examined for RVF-specific IgM antibody by ELISA. A subset of 2,263 sera were examined for evidence of Crimean-Congo hemorrhagic fever (CCHF) virus antibody by an IgG-specific ELISA. Antibody against CCHF virus was found to be most prevalent in adult cattle (422 of 732 or 57.7{\%} positive) sampled at nine locations in the Niamey area. The highest prevalence for RVF neutralizing antibodies was found in camels from the Agadez Department with 67 (47.5{\%}) of 141 positive. The results indicate that both CCHF and RVF viruses are circulating in Niger and are potential zoonotic health risks.",
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