Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts

R. M. Goldblum, A. A. O'Donell, D. Pyron, R. M. Goldblum, R. P. Pelley, A. A. O'Donell, J. P. Heggers

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

Silicone elastomers used to make medical implants and prostheses are generally believed to be biologically inert. However, we have seen two patients who showed severe, apparently immune- mediated, reactions to ventriculoperitoneal (VP) shunts. We used an enzyme-linked immunosorbent assay in which Silastic tubing served as the solid-phase antigen to test serum from the two patients, five other VP shunt patients without inflammatory reactions, and nine healthy adults. IgG binding to Silastic tubing was consistently higher in the two patients than in the healthy or patient controls. The IgG seemed to be binding specifically, since IgG Fab fragments also bound to the tubing, and preincubation of serum with Silastic or silylated proteins removed most of the activity. These findings show that specific immune reactivity to elastomers of polydimethylsiloxane can develop in human beings.

Original languageEnglish (US)
Pages (from-to)510-513
Number of pages4
JournalThe Lancet
Volume340
Issue number8818
DOIs
StatePublished - Aug 29 1992

Fingerprint

Ventriculoperitoneal Shunt
Silicone Elastomers
Antibodies
Immunoglobulin G
Elastomers
Immunoglobulin Fab Fragments
Serum
Prostheses and Implants
Enzyme-Linked Immunosorbent Assay
Antigens
baysilon
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Goldblum, R. M., O'Donell, A. A., Pyron, D., Goldblum, R. M., Pelley, R. P., O'Donell, A. A., & Heggers, J. P. (1992). Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts. The Lancet, 340(8818), 510-513. https://doi.org/10.1016/0140-6736(92)91710-P

Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts. / Goldblum, R. M.; O'Donell, A. A.; Pyron, D.; Goldblum, R. M.; Pelley, R. P.; O'Donell, A. A.; Heggers, J. P.

In: The Lancet, Vol. 340, No. 8818, 29.08.1992, p. 510-513.

Research output: Contribution to journalArticle

Goldblum, RM, O'Donell, AA, Pyron, D, Goldblum, RM, Pelley, RP, O'Donell, AA & Heggers, JP 1992, 'Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts', The Lancet, vol. 340, no. 8818, pp. 510-513. https://doi.org/10.1016/0140-6736(92)91710-P
Goldblum RM, O'Donell AA, Pyron D, Goldblum RM, Pelley RP, O'Donell AA et al. Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts. The Lancet. 1992 Aug 29;340(8818):510-513. https://doi.org/10.1016/0140-6736(92)91710-P
Goldblum, R. M. ; O'Donell, A. A. ; Pyron, D. ; Goldblum, R. M. ; Pelley, R. P. ; O'Donell, A. A. ; Heggers, J. P. / Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts. In: The Lancet. 1992 ; Vol. 340, No. 8818. pp. 510-513.
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