Antibody responses to Fermi antirabies vaccine in 21 patients bitten by a rabid jackal

Boulos A.M. Botros; Thomas G. Ksiazek; Robert Mc N. Scott; Fibi A. Kolta

doi:10.1016/0035-9203(87)90142-8

Antibody responses to Fermi antirabies vaccine in 21 patients bitten by a rabid jackal

Boulos A.M. Botros, Thomas G. Ksiazek, Robert Mc N. Scott, Fibi A. Kolta

Research output: Contribution to journal › Article › peer-review

Abstract

In a village in Upper Egypt, 21 persons were bitten by a rabid jackal. All received antirabies vaccine of the Fermi type within a few hours after the exposure. Antirabies hyperimmune serum was not administered. Three of the 21 victims died on days 16, 17 and 27 after exposure. Blood samples were obtained from 19 of the 21 bitten persons 5 days after completion of a series of 20 vaccine doses. Sera were tested for rabies antibodies by the indirect fluorescent antibody test (IFAT) and enzyme-linked immunosorbent assay (ELISA) test. All 19 persons developed rabies antibodies detectable by these techniques. IFAT titres ranged from 128 to ≥ 1024. ELISA antiglycoprotein titres were generally low, ranging from 0·7 to 18 iu/ml of serum.

Original language	English (US)
Pages (from-to)	381-382
Number of pages	2
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	81
Issue number	3
DOIs	https://doi.org/10.1016/0035-9203(87)90142-8
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1016/0035-9203(87)90142-8

Cite this

@article{a933c2fd2c3245899816886ffb06aa06,

title = "Antibody responses to Fermi antirabies vaccine in 21 patients bitten by a rabid jackal",

abstract = "In a village in Upper Egypt, 21 persons were bitten by a rabid jackal. All received antirabies vaccine of the Fermi type within a few hours after the exposure. Antirabies hyperimmune serum was not administered. Three of the 21 victims died on days 16, 17 and 27 after exposure. Blood samples were obtained from 19 of the 21 bitten persons 5 days after completion of a series of 20 vaccine doses. Sera were tested for rabies antibodies by the indirect fluorescent antibody test (IFAT) and enzyme-linked immunosorbent assay (ELISA) test. All 19 persons developed rabies antibodies detectable by these techniques. IFAT titres ranged from 128 to ≥ 1024. ELISA antiglycoprotein titres were generally low, ranging from 0·7 to 18 iu/ml of serum.",

author = "Botros, {Boulos A.M.} and Ksiazek, {Thomas G.} and Scott, {Robert Mc N.} and Kolta, {Fibi A.}",

note = "Funding Information: This work was SUDDOrted bv Naval Medical Research and Development Command, NMC, NCR, Reprint request to: ResearFhP ublications Division, U.S. ZyaI Medd ResearchU nit No. 3, FPO New York 09527,",

year = "1987",

doi = "10.1016/0035-9203(87)90142-8",

language = "English (US)",

volume = "81",

pages = "381--382",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

issn = "0035-9203",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Antibody responses to Fermi antirabies vaccine in 21 patients bitten by a rabid jackal

AU - Botros, Boulos A.M.

AU - Ksiazek, Thomas G.

AU - Scott, Robert Mc N.

AU - Kolta, Fibi A.

N1 - Funding Information: This work was SUDDOrted bv Naval Medical Research and Development Command, NMC, NCR, Reprint request to: ResearFhP ublications Division, U.S. ZyaI Medd ResearchU nit No. 3, FPO New York 09527,

PY - 1987

Y1 - 1987

N2 - In a village in Upper Egypt, 21 persons were bitten by a rabid jackal. All received antirabies vaccine of the Fermi type within a few hours after the exposure. Antirabies hyperimmune serum was not administered. Three of the 21 victims died on days 16, 17 and 27 after exposure. Blood samples were obtained from 19 of the 21 bitten persons 5 days after completion of a series of 20 vaccine doses. Sera were tested for rabies antibodies by the indirect fluorescent antibody test (IFAT) and enzyme-linked immunosorbent assay (ELISA) test. All 19 persons developed rabies antibodies detectable by these techniques. IFAT titres ranged from 128 to ≥ 1024. ELISA antiglycoprotein titres were generally low, ranging from 0·7 to 18 iu/ml of serum.

AB - In a village in Upper Egypt, 21 persons were bitten by a rabid jackal. All received antirabies vaccine of the Fermi type within a few hours after the exposure. Antirabies hyperimmune serum was not administered. Three of the 21 victims died on days 16, 17 and 27 after exposure. Blood samples were obtained from 19 of the 21 bitten persons 5 days after completion of a series of 20 vaccine doses. Sera were tested for rabies antibodies by the indirect fluorescent antibody test (IFAT) and enzyme-linked immunosorbent assay (ELISA) test. All 19 persons developed rabies antibodies detectable by these techniques. IFAT titres ranged from 128 to ≥ 1024. ELISA antiglycoprotein titres were generally low, ranging from 0·7 to 18 iu/ml of serum.

UR - http://www.scopus.com/inward/record.url?scp=0023083662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023083662&partnerID=8YFLogxK

U2 - 10.1016/0035-9203(87)90142-8

DO - 10.1016/0035-9203(87)90142-8

M3 - Article

C2 - 3686632

AN - SCOPUS:0023083662

SN - 0035-9203

VL - 81

SP - 381

EP - 382

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 3

ER -

Antibody responses to Fermi antirabies vaccine in 21 patients bitten by a rabid jackal

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this