Antibody responses to Fermi antirabies vaccine in 21 patients bitten by a rabid jackal

Boulos A M Botros, Thomas Ksiazek, Robert McN Scott, Fibi A. Kolta

Research output: Contribution to journalArticle

Abstract

In a village in Upper Egypt, 21 persons were bitten by a rabid jackal. All received antirabies vaccine of the Fermi type within a few hours after the exposure. Antirabies hyperimmune serum was not administered. Three of the 21 victims died on days 16, 17 and 27 after exposure. Blood samples were obtained from 19 of the 21 bitten persons 5 days after completion of a series of 20 vaccine doses. Sera were tested for rabies antibodies by the indirect fluorescent antibody test (IFAT) and enzyme-linked immunosorbent assay (ELISA) test. All 19 persons developed rabies antibodies detectable by these techniques. IFAT titres ranged from 128 to ≥ 1024. ELISA antiglycoprotein titres were generally low, ranging from 0·7 to 18 iu/ml of serum.

Original languageEnglish (US)
Pages (from-to)381-382
Number of pages2
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume81
Issue number3
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Jackals
Antibody Formation
Vaccines
Rabies
Antibodies
Serum
Enzyme-Linked Immunosorbent Assay
Egypt

ASJC Scopus subject areas

  • Parasitology
  • Medicine(all)

Cite this

Antibody responses to Fermi antirabies vaccine in 21 patients bitten by a rabid jackal. / Botros, Boulos A M; Ksiazek, Thomas; Scott, Robert McN; Kolta, Fibi A.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 81, No. 3, 1987, p. 381-382.

Research output: Contribution to journalArticle

@article{a933c2fd2c3245899816886ffb06aa06,
title = "Antibody responses to Fermi antirabies vaccine in 21 patients bitten by a rabid jackal",
abstract = "In a village in Upper Egypt, 21 persons were bitten by a rabid jackal. All received antirabies vaccine of the Fermi type within a few hours after the exposure. Antirabies hyperimmune serum was not administered. Three of the 21 victims died on days 16, 17 and 27 after exposure. Blood samples were obtained from 19 of the 21 bitten persons 5 days after completion of a series of 20 vaccine doses. Sera were tested for rabies antibodies by the indirect fluorescent antibody test (IFAT) and enzyme-linked immunosorbent assay (ELISA) test. All 19 persons developed rabies antibodies detectable by these techniques. IFAT titres ranged from 128 to ≥ 1024. ELISA antiglycoprotein titres were generally low, ranging from 0·7 to 18 iu/ml of serum.",
author = "Botros, {Boulos A M} and Thomas Ksiazek and Scott, {Robert McN} and Kolta, {Fibi A.}",
year = "1987",
doi = "10.1016/0035-9203(87)90142-8",
language = "English (US)",
volume = "81",
pages = "381--382",
journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",
issn = "0035-9203",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Antibody responses to Fermi antirabies vaccine in 21 patients bitten by a rabid jackal

AU - Botros, Boulos A M

AU - Ksiazek, Thomas

AU - Scott, Robert McN

AU - Kolta, Fibi A.

PY - 1987

Y1 - 1987

N2 - In a village in Upper Egypt, 21 persons were bitten by a rabid jackal. All received antirabies vaccine of the Fermi type within a few hours after the exposure. Antirabies hyperimmune serum was not administered. Three of the 21 victims died on days 16, 17 and 27 after exposure. Blood samples were obtained from 19 of the 21 bitten persons 5 days after completion of a series of 20 vaccine doses. Sera were tested for rabies antibodies by the indirect fluorescent antibody test (IFAT) and enzyme-linked immunosorbent assay (ELISA) test. All 19 persons developed rabies antibodies detectable by these techniques. IFAT titres ranged from 128 to ≥ 1024. ELISA antiglycoprotein titres were generally low, ranging from 0·7 to 18 iu/ml of serum.

AB - In a village in Upper Egypt, 21 persons were bitten by a rabid jackal. All received antirabies vaccine of the Fermi type within a few hours after the exposure. Antirabies hyperimmune serum was not administered. Three of the 21 victims died on days 16, 17 and 27 after exposure. Blood samples were obtained from 19 of the 21 bitten persons 5 days after completion of a series of 20 vaccine doses. Sera were tested for rabies antibodies by the indirect fluorescent antibody test (IFAT) and enzyme-linked immunosorbent assay (ELISA) test. All 19 persons developed rabies antibodies detectable by these techniques. IFAT titres ranged from 128 to ≥ 1024. ELISA antiglycoprotein titres were generally low, ranging from 0·7 to 18 iu/ml of serum.

UR - http://www.scopus.com/inward/record.url?scp=0023083662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023083662&partnerID=8YFLogxK

U2 - 10.1016/0035-9203(87)90142-8

DO - 10.1016/0035-9203(87)90142-8

M3 - Article

C2 - 3686632

AN - SCOPUS:0023083662

VL - 81

SP - 381

EP - 382

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 3

ER -