Anticancer and antimetastatic activities of renieramyein M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells

Hasseri Halim, Preedakorn Chunhacha, Khanit Suwanborirux, Pithi Chanvorachote

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Renieramycin M, has been shown to exhibit promising anticancer activity against some cancer cell lines; however, the underlying mechanism remains unknown. Materials and Methods: Renieramycin M was isolated from the blue sponge Xestospongia sp. Anticancer and antimetastatic activities of renieramycin M were investigated in human non-small cell lung cancer cells. Results: Renieramycin M treatment caused p53 activation, which subsequently down-regulated anti-apoptotic MCL-1 and BCL-2 proteins, while the level of pro-apoptotic BAX protein was not altered. The subtoxic concentrations of renieramycin M significantly decreased invasion and migration abilities of cancer cells. In addition, this compound showed a strong inhibitory effect on anchorage-independent growth of the cells. Conclusion: These results reveal that renieramycin M induced lung cancer cells apoptosis through p53-dependent pathway and the compound may inhibit progression and metastasis of lung cancer cells.

Original languageEnglish (US)
Pages (from-to)193-201
Number of pages9
JournalAnticancer Research
Volume31
Issue number1
StatePublished - Jan 2011
Externally publishedYes

Fingerprint

Tetrahydroisoquinolines
Alkaloids
Non-Small Cell Lung Carcinoma
Xestospongia
Lung Neoplasms
Apoptosis Regulatory Proteins
Porifera
renieramycin M
Neoplasms
Apoptosis
Neoplasm Metastasis
Cell Line
Growth

Keywords

  • Anoikis
  • Invasion
  • Lung cancer cells
  • Metastasis
  • Migration
  • Renieramycin M

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Anticancer and antimetastatic activities of renieramyein M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells. / Halim, Hasseri; Chunhacha, Preedakorn; Suwanborirux, Khanit; Chanvorachote, Pithi.

In: Anticancer Research, Vol. 31, No. 1, 01.2011, p. 193-201.

Research output: Contribution to journalArticle

Halim, Hasseri ; Chunhacha, Preedakorn ; Suwanborirux, Khanit ; Chanvorachote, Pithi. / Anticancer and antimetastatic activities of renieramyein M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells. In: Anticancer Research. 2011 ; Vol. 31, No. 1. pp. 193-201.
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