Anticancer and antimetastatic activities of renieramyein M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells

Hasseri Halim, Preedakorn Chunhacha, Khanit Suwanborirux, Pithi Chanvorachote

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Background: Renieramycin M, has been shown to exhibit promising anticancer activity against some cancer cell lines; however, the underlying mechanism remains unknown. Materials and Methods: Renieramycin M was isolated from the blue sponge Xestospongia sp. Anticancer and antimetastatic activities of renieramycin M were investigated in human non-small cell lung cancer cells. Results: Renieramycin M treatment caused p53 activation, which subsequently down-regulated anti-apoptotic MCL-1 and BCL-2 proteins, while the level of pro-apoptotic BAX protein was not altered. The subtoxic concentrations of renieramycin M significantly decreased invasion and migration abilities of cancer cells. In addition, this compound showed a strong inhibitory effect on anchorage-independent growth of the cells. Conclusion: These results reveal that renieramycin M induced lung cancer cells apoptosis through p53-dependent pathway and the compound may inhibit progression and metastasis of lung cancer cells.

Original languageEnglish (US)
Pages (from-to)193-201
Number of pages9
JournalAnticancer Research
Volume31
Issue number1
StatePublished - Jan 1 2011

    Fingerprint

Keywords

  • Anoikis
  • Invasion
  • Lung cancer cells
  • Metastasis
  • Migration
  • Renieramycin M

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this