Anticonvulsant prolongation of survival in adult murine lymphocytic choriomeningitis: I. Drug treatment and virologic studies

David L. Camenga, David H. Walker, Frederick A. Murphy

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Lymphocytic choriomeningitis virus-induced central nervous system disease is characterized by death during a seizure approximately seven days after intracerebral inoculation. This process is mediated by thymus dependent lymphocytes, sensitized against viral antigens. Various forms of immunosuppressive treatment prevent the seizure death and produce persistently infected survivors. In this study, anticonvulsant treatment (particularly diazepam treatment) of LCM virus infected mice prolonged survival without affecting viral replication, or suppressing immune responsiveness. This prolongation of life did not lead to a reversal of pathologic processes and there were no survivors. However, anticonvulsant treatment permitted study of more advanced stages of the choriomeningitis than has previously been possible.

Original languageEnglish (US)
Pages (from-to)9-20
Number of pages12
JournalJournal of Neuropathology and Experimental Neurology
Volume36
Issue number1
DOIs
StatePublished - Jan 1977
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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