Antidiabetic and antihyperlipidemic effects of the stem of Musa sapientum Linn. in streptozotocin-induced diabetic rats

Piyush Dikshit, Kirtikar Shukla, Mool Kumar Tyagi, Piyush Garg, Jasvindar K. Gambhir, Rimi Shukla

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Musa sapientum Linn. is a herbaceous plant of the Musaceae family. It has been used in India for the treatment of gastric ulcer, hypertension, diarrhea, dysentery, and diabetes. The antidiabetic effect of the fruit, root, and flower has been demonstrated. The aim of the present study was to assess the antidiabetic and antihyperlipidemic effects of the stem of M. sapientum Linn. Methods: Diabetes was induced in rats by streptozotocin injection (45mg/kg, i.p.). Diabetic rats were treated for 2weeks with different doses of lyophilized stem juice of M. sapientum Linn. (25, 50, and 100mg/kg) to select the most effective dose. The effects of 4weeks treatment with this dose (50mg/kg) on fasting and postprandial plasma glucose (FPG, PPG) levels, body weight, lipid profile, HbA1c, insulin, liver enzymes (i.e. glucokinase, glucose-6-phosphatase and 3-hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase) and muscle and liver glycogen were evaluated. Results: The most effective dose of lyophilized stem juice of M. sapientum Linn. was 50mg/kg. Four weeks treatment with this dose resulted in significant decreases in FPG and PPG (P

Original languageEnglish (US)
Pages (from-to)378-385
Number of pages8
JournalJournal of Diabetes
Volume4
Issue number4
DOIs
StatePublished - Dec 2012
Externally publishedYes

Fingerprint

Hypolipidemic Agents
Musa
Streptozocin
Hypoglycemic Agents
Musaceae
Glucokinase
Glucose-6-Phosphatase
Dysentery
Liver Glycogen
Stomach Ulcer
India
Diarrhea
Fasting
Fruit
Oxidoreductases
Therapeutics
Body Weight
Insulin
Hypertension
Lipids

Keywords

  • Diabetes
  • Musa sapientum
  • Stem juice
  • Streptozotocin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Antidiabetic and antihyperlipidemic effects of the stem of Musa sapientum Linn. in streptozotocin-induced diabetic rats. / Dikshit, Piyush; Shukla, Kirtikar; Tyagi, Mool Kumar; Garg, Piyush; Gambhir, Jasvindar K.; Shukla, Rimi.

In: Journal of Diabetes, Vol. 4, No. 4, 12.2012, p. 378-385.

Research output: Contribution to journalArticle

Dikshit, Piyush ; Shukla, Kirtikar ; Tyagi, Mool Kumar ; Garg, Piyush ; Gambhir, Jasvindar K. ; Shukla, Rimi. / Antidiabetic and antihyperlipidemic effects of the stem of Musa sapientum Linn. in streptozotocin-induced diabetic rats. In: Journal of Diabetes. 2012 ; Vol. 4, No. 4. pp. 378-385.
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