Antigen presentation of mucosal pathogens

The players and the rules

Victor Reyes, Gang Ye, Pearay L. Ogra, Roberto Garofalo

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A vast number of infectious pathogens gain entry into the host through mucosal surfaces, which have a much greater total surface area than the skin. Since the mucosa is continuously exposed to those pathogens, the development of an effective local immune response is of utmost importance. An obligatory step in the development of most immune responses is the presentation of antigens by specialized accessory cells, termed antigen-presenting cells (APC), to T lymphocytes. The recognition of antigens by T cells is largely determined by how the antigens are handled by the APC. Complex antigen-processing events generate a selected set of peptides which ultimately become associated with MHC molecules. The type of MHC molecules that bind the peptides in turn determine what T lymphocyte subset recognizes the peptides. Thus, an understanding of the molecular and cellular processes preceding the T cell recognition event is a prerequisite for understanding how mucosal immune responses develop, as well as for investigating alternative approaches to vaccine development and therapeutic strategies to control autoimmune diseases. This review discusses the cell biology of antigen processing and how various APC populations may participate in mucosal responses.

Original languageEnglish (US)
Pages (from-to)103-114
Number of pages12
JournalInternational Archives of Allergy and Immunology
Volume112
Issue number2
StatePublished - Feb 1997

Fingerprint

Antigen Presentation
Antigen-Presenting Cells
T-Lymphocytes
Peptides
Antigens
Mucosal Immunity
T-Lymphocyte Subsets
Autoimmune Diseases
Cell Biology
Mucous Membrane
Vaccines
Skin
Population
Therapeutics

Keywords

  • Antigen processing
  • Antigen-presenting cells
  • Cell biology
  • Mucosal immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Antigen presentation of mucosal pathogens : The players and the rules. / Reyes, Victor; Ye, Gang; Ogra, Pearay L.; Garofalo, Roberto.

In: International Archives of Allergy and Immunology, Vol. 112, No. 2, 02.1997, p. 103-114.

Research output: Contribution to journalArticle

@article{f66453a7f22f44839acf02d60f724b58,
title = "Antigen presentation of mucosal pathogens: The players and the rules",
abstract = "A vast number of infectious pathogens gain entry into the host through mucosal surfaces, which have a much greater total surface area than the skin. Since the mucosa is continuously exposed to those pathogens, the development of an effective local immune response is of utmost importance. An obligatory step in the development of most immune responses is the presentation of antigens by specialized accessory cells, termed antigen-presenting cells (APC), to T lymphocytes. The recognition of antigens by T cells is largely determined by how the antigens are handled by the APC. Complex antigen-processing events generate a selected set of peptides which ultimately become associated with MHC molecules. The type of MHC molecules that bind the peptides in turn determine what T lymphocyte subset recognizes the peptides. Thus, an understanding of the molecular and cellular processes preceding the T cell recognition event is a prerequisite for understanding how mucosal immune responses develop, as well as for investigating alternative approaches to vaccine development and therapeutic strategies to control autoimmune diseases. This review discusses the cell biology of antigen processing and how various APC populations may participate in mucosal responses.",
keywords = "Antigen processing, Antigen-presenting cells, Cell biology, Mucosal immunity",
author = "Victor Reyes and Gang Ye and Ogra, {Pearay L.} and Roberto Garofalo",
year = "1997",
month = "2",
language = "English (US)",
volume = "112",
pages = "103--114",
journal = "International Archives of Allergy and Immunology",
issn = "1018-2438",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Antigen presentation of mucosal pathogens

T2 - The players and the rules

AU - Reyes, Victor

AU - Ye, Gang

AU - Ogra, Pearay L.

AU - Garofalo, Roberto

PY - 1997/2

Y1 - 1997/2

N2 - A vast number of infectious pathogens gain entry into the host through mucosal surfaces, which have a much greater total surface area than the skin. Since the mucosa is continuously exposed to those pathogens, the development of an effective local immune response is of utmost importance. An obligatory step in the development of most immune responses is the presentation of antigens by specialized accessory cells, termed antigen-presenting cells (APC), to T lymphocytes. The recognition of antigens by T cells is largely determined by how the antigens are handled by the APC. Complex antigen-processing events generate a selected set of peptides which ultimately become associated with MHC molecules. The type of MHC molecules that bind the peptides in turn determine what T lymphocyte subset recognizes the peptides. Thus, an understanding of the molecular and cellular processes preceding the T cell recognition event is a prerequisite for understanding how mucosal immune responses develop, as well as for investigating alternative approaches to vaccine development and therapeutic strategies to control autoimmune diseases. This review discusses the cell biology of antigen processing and how various APC populations may participate in mucosal responses.

AB - A vast number of infectious pathogens gain entry into the host through mucosal surfaces, which have a much greater total surface area than the skin. Since the mucosa is continuously exposed to those pathogens, the development of an effective local immune response is of utmost importance. An obligatory step in the development of most immune responses is the presentation of antigens by specialized accessory cells, termed antigen-presenting cells (APC), to T lymphocytes. The recognition of antigens by T cells is largely determined by how the antigens are handled by the APC. Complex antigen-processing events generate a selected set of peptides which ultimately become associated with MHC molecules. The type of MHC molecules that bind the peptides in turn determine what T lymphocyte subset recognizes the peptides. Thus, an understanding of the molecular and cellular processes preceding the T cell recognition event is a prerequisite for understanding how mucosal immune responses develop, as well as for investigating alternative approaches to vaccine development and therapeutic strategies to control autoimmune diseases. This review discusses the cell biology of antigen processing and how various APC populations may participate in mucosal responses.

KW - Antigen processing

KW - Antigen-presenting cells

KW - Cell biology

KW - Mucosal immunity

UR - http://www.scopus.com/inward/record.url?scp=0031023858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031023858&partnerID=8YFLogxK

M3 - Article

VL - 112

SP - 103

EP - 114

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

IS - 2

ER -