Antigenic and genetic relationships among Rift Valley fever virus and other selected members of the genus phlebovirus (Bunyaviridae)

Fangling Xu, Dongying Liu, Marcio R T Nunes, Amelia P A Travassos Da Rosa, Robert B. Tesh, Shu Yuan Xiao

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Preliminary serologic data indicated that two South American phleboviruses (Belterra virus [BELTV] and Icoaraci virus [ICOV]) may be related to Rift Valley fever virus (RVFV), an African phlebovirus that causes severe hepatitis and hemorrhagic fever in humans. To further define this relationship and to investigate the underlying genetic basis, comparative serologic and genetic sequence analyses were performed with RVFV and five other New World phleboviruses (ICOV, BELTV, Salobo virus, Joa virus, and Frijoles virus). Serologically, a one-way cross reaction was confirmed between antibodies against these New World viruses and RVFV antigen. In contrast, phylogenetic analysis demonstrated clear separation of these viruses from RVFV, into distinct phylogenies, based on sequences of the small, medium, and large RNA segments.

Original languageEnglish (US)
Pages (from-to)1194-1200
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume76
Issue number6
StatePublished - Jun 2007

Fingerprint

Phlebovirus
Rift Valley fever virus
Bunyaviridae
Viruses
Cross Reactions
Phylogeny
Hepatitis
Sequence Analysis
Fever

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Antigenic and genetic relationships among Rift Valley fever virus and other selected members of the genus phlebovirus (Bunyaviridae). / Xu, Fangling; Liu, Dongying; Nunes, Marcio R T; Travassos Da Rosa, Amelia P A; Tesh, Robert B.; Xiao, Shu Yuan.

In: American Journal of Tropical Medicine and Hygiene, Vol. 76, No. 6, 06.2007, p. 1194-1200.

Research output: Contribution to journalArticle

Xu, Fangling ; Liu, Dongying ; Nunes, Marcio R T ; Travassos Da Rosa, Amelia P A ; Tesh, Robert B. ; Xiao, Shu Yuan. / Antigenic and genetic relationships among Rift Valley fever virus and other selected members of the genus phlebovirus (Bunyaviridae). In: American Journal of Tropical Medicine and Hygiene. 2007 ; Vol. 76, No. 6. pp. 1194-1200.
@article{f7a44ce05d9e437488e4a0777e78abb0,
title = "Antigenic and genetic relationships among Rift Valley fever virus and other selected members of the genus phlebovirus (Bunyaviridae)",
abstract = "Preliminary serologic data indicated that two South American phleboviruses (Belterra virus [BELTV] and Icoaraci virus [ICOV]) may be related to Rift Valley fever virus (RVFV), an African phlebovirus that causes severe hepatitis and hemorrhagic fever in humans. To further define this relationship and to investigate the underlying genetic basis, comparative serologic and genetic sequence analyses were performed with RVFV and five other New World phleboviruses (ICOV, BELTV, Salobo virus, Joa virus, and Frijoles virus). Serologically, a one-way cross reaction was confirmed between antibodies against these New World viruses and RVFV antigen. In contrast, phylogenetic analysis demonstrated clear separation of these viruses from RVFV, into distinct phylogenies, based on sequences of the small, medium, and large RNA segments.",
author = "Fangling Xu and Dongying Liu and Nunes, {Marcio R T} and {Travassos Da Rosa}, {Amelia P A} and Tesh, {Robert B.} and Xiao, {Shu Yuan}",
year = "2007",
month = "6",
language = "English (US)",
volume = "76",
pages = "1194--1200",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "6",

}

TY - JOUR

T1 - Antigenic and genetic relationships among Rift Valley fever virus and other selected members of the genus phlebovirus (Bunyaviridae)

AU - Xu, Fangling

AU - Liu, Dongying

AU - Nunes, Marcio R T

AU - Travassos Da Rosa, Amelia P A

AU - Tesh, Robert B.

AU - Xiao, Shu Yuan

PY - 2007/6

Y1 - 2007/6

N2 - Preliminary serologic data indicated that two South American phleboviruses (Belterra virus [BELTV] and Icoaraci virus [ICOV]) may be related to Rift Valley fever virus (RVFV), an African phlebovirus that causes severe hepatitis and hemorrhagic fever in humans. To further define this relationship and to investigate the underlying genetic basis, comparative serologic and genetic sequence analyses were performed with RVFV and five other New World phleboviruses (ICOV, BELTV, Salobo virus, Joa virus, and Frijoles virus). Serologically, a one-way cross reaction was confirmed between antibodies against these New World viruses and RVFV antigen. In contrast, phylogenetic analysis demonstrated clear separation of these viruses from RVFV, into distinct phylogenies, based on sequences of the small, medium, and large RNA segments.

AB - Preliminary serologic data indicated that two South American phleboviruses (Belterra virus [BELTV] and Icoaraci virus [ICOV]) may be related to Rift Valley fever virus (RVFV), an African phlebovirus that causes severe hepatitis and hemorrhagic fever in humans. To further define this relationship and to investigate the underlying genetic basis, comparative serologic and genetic sequence analyses were performed with RVFV and five other New World phleboviruses (ICOV, BELTV, Salobo virus, Joa virus, and Frijoles virus). Serologically, a one-way cross reaction was confirmed between antibodies against these New World viruses and RVFV antigen. In contrast, phylogenetic analysis demonstrated clear separation of these viruses from RVFV, into distinct phylogenies, based on sequences of the small, medium, and large RNA segments.

UR - http://www.scopus.com/inward/record.url?scp=34547578806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547578806&partnerID=8YFLogxK

M3 - Article

VL - 76

SP - 1194

EP - 1200

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 6

ER -