Antigenic diversity of respiratory syncytial virus subgroup B strains circulating during a community outbreak of infection

Gordana Mlinaric‐Galinovic, Tasnee Chonmaitree, Patricia A. Cane, Craig R. Pringle, Pearay L. Ogra

    Research output: Contribution to journalArticle

    19 Scopus citations

    Abstract

    The epidemiological characteristics and relationship between respiratory syncytial virus (RSV) subgroup and virulence during an outbreak of RSV infection occurring in Southeast Texas in the winter season 1991/92 are described. Fiftytwo infants and children were diagnosed with RSV infection by rapid viral antigen detection and/or viral isolation. Subgrouping of the isolates was carried out using 11‐monoclonal antibodies. Ten isolates were found to be subgroup B, and 8 isolates were subgroup A. The subgroup B strains showed 3 different patterns of reaction with monoclonal antibodies; one of these subgroups was examined further by restriction analysis of parts of its nucleocapsid and attachment protein genes. The peak of RSV outbreak was in December 1991. Both subtypes A and B circulated simultaneously in the same territory, and caused lower respiratory tract infections in similar proportions. The more frequent occurrence of the B subgroup and the diversity of its simultaneously circulated RSV strains have made this outbreak unusual. © 1994 Wiley‐Liss, Inc.

    Original languageEnglish (US)
    Pages (from-to)380-384
    Number of pages5
    JournalJournal of Medical Virology
    Volume42
    Issue number4
    DOIs
    StatePublished - Apr 1994

    Keywords

    • BRSV subgroups
    • G‐gene restriction pattern
    • acute respiratory viral infection
    • monoclonal antibodies

    ASJC Scopus subject areas

    • Virology
    • Infectious Diseases

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