Antigenic diversity of respiratory syncytial virus subgroup B strains circulating during a community outbreak of infection

G. Mlinaric-Galinovic, T. Chonmaitree, P. A. Cane, C. R. Pringle, P. L. Ogra

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The epidemiological characteristics and relationship between respiratory syncytial virus (RSV) subgroup and virulence during an outbreak of RSV infection occurring in Southeast Texas in the winter season 1991/92 are described. Fifty-two infants and children were diagnosed with RSV infection by rapid viral antigen detection and/or viral isolation. Subgrouping of the isolates was carried out using 11-monoclonal antibodies. Ten isolates were found to be subgroup B, and 8 isolates were subgroup A. The subgroup B strains showed 3 different patterns of reaction with monoclonal antibodies; one of these subgroups was examined further by restriction analysis of parts of its nucleocapsid and attachment protein genes. The peak of RSV outbreak was in December 1991 . Both subtypes A and B circulated simultaneously in the same territory, and caused lower respiratory tract infections in similar proportions. The more frequent occurrence of the B subgroup and the diversity of its simultaneously circulated RSV strains have made this outbreak unusual.

Original languageEnglish (US)
Pages (from-to)380-384
Number of pages5
JournalJournal of Medical Virology
Volume42
Issue number4
StatePublished - 1994

Fingerprint

Antigenic Variation
Respiratory Syncytial Viruses
Disease Outbreaks
Respiratory Syncytial Virus Infections
Infection
Monoclonal Antibodies
Nucleocapsid Proteins
Viral Antigens
Respiratory Tract Infections
Virulence
Genes

Keywords

  • acute respiratory viral infection
  • G-gene restriction pattern
  • monoclonal antibodies
  • RSV subgroups

ASJC Scopus subject areas

  • Virology

Cite this

Mlinaric-Galinovic, G., Chonmaitree, T., Cane, P. A., Pringle, C. R., & Ogra, P. L. (1994). Antigenic diversity of respiratory syncytial virus subgroup B strains circulating during a community outbreak of infection. Journal of Medical Virology, 42(4), 380-384.

Antigenic diversity of respiratory syncytial virus subgroup B strains circulating during a community outbreak of infection. / Mlinaric-Galinovic, G.; Chonmaitree, T.; Cane, P. A.; Pringle, C. R.; Ogra, P. L.

In: Journal of Medical Virology, Vol. 42, No. 4, 1994, p. 380-384.

Research output: Contribution to journalArticle

Mlinaric-Galinovic, G, Chonmaitree, T, Cane, PA, Pringle, CR & Ogra, PL 1994, 'Antigenic diversity of respiratory syncytial virus subgroup B strains circulating during a community outbreak of infection', Journal of Medical Virology, vol. 42, no. 4, pp. 380-384.
Mlinaric-Galinovic, G. ; Chonmaitree, T. ; Cane, P. A. ; Pringle, C. R. ; Ogra, P. L. / Antigenic diversity of respiratory syncytial virus subgroup B strains circulating during a community outbreak of infection. In: Journal of Medical Virology. 1994 ; Vol. 42, No. 4. pp. 380-384.
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