@article{054d9a553b674153b634e8a4033d7e59,
title = "Antigenic heterogeneity among phylogenetic clusters of influenza D viruses",
abstract = "Influenza (flu) D virus, a possible causative agent of bovine respiratory disease, is genetically classified into three clusters: D/OK-, D/660-, and D/Japan-lineages. To evaluate antigenic heterogeneity among these clusters, we compared antibody titers to each lineage virus using bovine sera collected over time following virus infection. Antibody titers to D/Japan-lineage virus rose rapidly in the acute phase of infection, and were 4 times higher than those to the other clustered viruses. In the later phase of infection, titers to D/Japan-lineage virus were equivalent to those to D/OK-lineage virus, and still higher than those to D/660-lineage virus. These results suggest the existence of common and lineage-specific antigenic epitopes in the hemagglutininesterase-fusion protein of flu D viruses.",
keywords = "Antigenicity, Cattle, Hemagglutinin-esterase-fusion protein, Influenza D virus, Serology",
author = "Tomoha Odagiri and Hiroho Ishida and Li, {Jun You} and Maiko Endo and Tomoya Kobayashi and Haruhiko Kamiki and Hiromichi Matsugo and Akiko Takenaka-Uema and Shin Murakami and Taisuke Horimoto",
note = "Funding Information: ACKNOWLEDGMENTS. We thank Dr. Benjamin Hause (Veterinary Diagnostic Laboratory, Kansas State University, U.S.A.) for the D/OK and D/NE viruses. T. H. is supported, in part, by a Grant-in-Aid for Scientific Research (A) (grant number: 26252048) and by Livestock Promotion Funds from the Japan Racing Association. S. M. is supported by a Grant-in-Aid for the Encouragement of Young Scientists (A) (grant number: 17H05042). Funding Information: We thank Dr. Benjamin Hause (Veterinary Diagnostic Laboratory, Kansas State University, U.S.A.) for the D/OK and D/NE viruses. T. H. is supported, in part, by a Grant-in-Aid for Scientific Research (A) (grant number: 26252048) and by Livestock Promotion Funds from the Japan Racing Association. S. M. is supported by a Grant-in-Aid for the Encouragement of Young Scientists (A) (grant number: 17H05042). Publisher Copyright: {\textcopyright} 2018 The Japanese Society of Veterinary Science.",
year = "2018",
month = aug,
doi = "10.1292/jvms.18-0157",
language = "English (US)",
volume = "80",
pages = "1241--1244",
journal = "Journal of Veterinary Medical Science",
issn = "0916-7250",
publisher = "Japanese Society of Veterinary Science",
number = "8",
}