Antigenic heterogeneity among phylogenetic clusters of influenza D viruses

Tomoha Odagiri, Hiroho Ishida, Jun You Li, Maiko Endo, Tomoya Kobayashi, Haruhiko Kamiki, Hiromichi Matsugo, Akiko Takenaka-Uema, Shin Murakami, Taisuke Horimoto

Research output: Contribution to journalComment/debatepeer-review

14 Scopus citations


Influenza (flu) D virus, a possible causative agent of bovine respiratory disease, is genetically classified into three clusters: D/OK-, D/660-, and D/Japan-lineages. To evaluate antigenic heterogeneity among these clusters, we compared antibody titers to each lineage virus using bovine sera collected over time following virus infection. Antibody titers to D/Japan-lineage virus rose rapidly in the acute phase of infection, and were 4 times higher than those to the other clustered viruses. In the later phase of infection, titers to D/Japan-lineage virus were equivalent to those to D/OK-lineage virus, and still higher than those to D/660-lineage virus. These results suggest the existence of common and lineage-specific antigenic epitopes in the hemagglutininesterase-fusion protein of flu D viruses.

Original languageEnglish (US)
Pages (from-to)1241-1244
Number of pages4
JournalJournal of Veterinary Medical Science
Issue number8
StatePublished - Aug 2018
Externally publishedYes


  • Antigenicity
  • Cattle
  • Hemagglutinin-esterase-fusion protein
  • Influenza D virus
  • Serology

ASJC Scopus subject areas

  • General Veterinary


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