Antihyperalgesic and anti-inflammatory effects of atorvastatin in chronic constriction injury-induced neuropathic pain in rats

Nitya N. Pathak, Venkanna Balaganur, Madhu C. Lingaraju, Amar S. More, Vinay Kant, Dhirendra Kumar, Dinesh Kumar, Surendra Kumar Tandan

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Atorvastatin is a 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor used in treatment of hypercholesterolemia and prevention of coronary heart disease. The aim of this study is to investigate the antihyperalgesic and anti-inflammatory effects of atorvastatin (3, 10, and 30 mg/kg by oral gavages for 14 days) in chronic constriction injury (CCI) model of neuropathic pain in rats. CCI caused significant increase in tumor necrosis factor-α, interleukin 1 beta, prostaglandin E2, along with matrix metalloproteases (MMP-2) and nerve growth factor (NGF) levels in sciatic nerve and spinal cord concomitant with mechanical and thermal hyperalgesia, which were significantly reduced by oral administration of atorvastatin for 14 days as compared to CCI rats. Our study demonstrated that atorvastatin attenuates neuropathic pain through inhibition of cytokines, MMP-2, and NGF in sciatic nerve and spinal cord suggesting that atorvastatin could be an additional therapeutic strategy in management of neuropathic pain.

Original languageEnglish (US)
Pages (from-to)1468-1478
Number of pages11
JournalInflammation
Volume36
Issue number6
DOIs
StatePublished - Dec 1 2013

Keywords

  • CCI
  • MMP-2
  • NGF
  • atorvastatin
  • neuropathic pain
  • proinflammatory cytokines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Pathak, N. N., Balaganur, V., Lingaraju, M. C., More, A. S., Kant, V., Kumar, D., Kumar, D., & Tandan, S. K. (2013). Antihyperalgesic and anti-inflammatory effects of atorvastatin in chronic constriction injury-induced neuropathic pain in rats. Inflammation, 36(6), 1468-1478. https://doi.org/10.1007/s10753-013-9688-x